EP 1045862 A1 20001025 - POLYPEPTIDES, DNA CODING THEREFOR, FORMULATIONS THEREOF, AND THEIR USE IN INHIBITING FACTOR XII ACTIVATION

Title (en)

POLYPEPTIDES, DNA CODING THEREFOR, FORMULATIONS THEREOF, AND THEIR USE IN INHIBITING FACTOR XII ACTIVATION

Title (de)

POLYPEPTIDE, DAFÜR KODIERENDE DNA, DIESE ENTHALTENDE ZUSAMMENSETZUNGEN, UND UND DEREN VERWENDUNG ZUR INHIBIERUNG VON FAKTOR XII AKTIVIERUNG

Title (fr)

POLYPEPTIDES, ADN LES CODANT, LEURS FORMULATIONS ET LEUR UTILISATION DANS L'INHIBITION DE L'ACTIVATION DU FACTEUR XII

Publication

EP 1045862 A1 20001025 (EN)

Application

EP 99901059 A 19990115

Priority

GB 9900147 W 19990115
GB 9800817 A 19980116

Abstract (en)

[origin: WO9936439A1] A polypeptide, derivable from a Haementeria leech, which polypeptide is suitable for inhibiting C1 esterase and/or factor XII activation is disclosed, together with a nucleic acid sequence encoding the polypeptide. The polypeptide may be used as a pharmaceutical formulation or in gene therapy to treat or prevent cardiovascular, inflammatory or auto-immune disorders.

IPC 1-7

C07K 14/815; C12N 15/12; C12N 15/70; C12N 1/21; A61K 38/58; A61K 48/00

IPC 8 full level

A61K 35/62 (2006.01); A61K 38/00 (2006.01); A61K 38/55 (2006.01); A61K 48/00 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 43/00 (2006.01); C07K 14/81 (2006.01); C07K 14/815 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01)

CPC (source: EP)

A61P 7/00 (2017.12); A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 9/10 (2017.12); A61P 29/00 (2017.12); A61P 37/02 (2017.12); A61P 43/00 (2017.12); C07K 14/811 (2013.01); C07K 14/8121 (2013.01); C07K 14/815 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

See references of WO 9936439A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

DOCDB simple family (publication)

WO 9936439 A1 19990722; AU 2068599 A 19990802; CA 2318358 A1 19990722; EP 1045862 A1 20001025; GB 9800817 D0 19980311; JP 2002508953 A 20020326

DOCDB simple family (application)

GB 9900147 W 19990115; AU 2068599 A 19990115; CA 2318358 A 19990115; EP 99901059 A 19990115; GB 9800817 A 19980116; JP 2000540154 A 19990115