EP 1045912 A1 20001025 - POLYKETIDES AND THEIR SYNTHESIS
Title (en)
POLYKETIDES AND THEIR SYNTHESIS
Title (de)
POLYKETIDE UND IHRE HERSTELLUNG
Title (fr)
POLYCETIDES ET LEUR SYNTHESE
Publication
Application
Priority
- GB 9900117 W 19990114
- GB 9800675 A 19980114
- GB 9800879 A 19980115
Abstract (en)
[origin: WO9936546A1] The present invention provides an extended polyketide synthase gene assembly comprising a loading module and a plurality of extension modules wherein a second nucleic acid portion, encoding at least one extension module, has been inserted into a first nucleic acid portion encoding the loading module and at least one, and preferably a plurality, of extension modules. Such extended genes are useful in the production of novel macrolides of larger size than the natural product, for example 16-membered ring macrolides instead of 14-membered ring macrolides.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C07D 493/08 (2006.01); C12N 1/21 (2006.01); C12N 15/52 (2006.01); C12P 19/62 (2006.01)
CPC (source: EP)
C07D 493/08 (2013.01); C12N 15/52 (2013.01); C12P 19/62 (2013.01)
Citation (search report)
See references of WO 9936546A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9936546 A1 19990722; AU 2066799 A 19990802; CA 2318365 A1 19990722; EP 1045912 A1 20001025; HR P20000474 A2 20001231; JP 2002508968 A 20020326
DOCDB simple family (application)
GB 9900117 W 19990114; AU 2066799 A 19990114; CA 2318365 A 19990114; EP 99901036 A 19990114; HR P20000474 A 20000714; JP 2000540248 A 19990114