Global Patent Index - EP 1045926 A2

EP 1045926 A2 2000-10-25 - GENE FAMILY WITH TRANSFORMATION MODULATING ACTIVITY

Title (en)

GENE FAMILY WITH TRANSFORMATION MODULATING ACTIVITY

Title (de)

EINE FAMILIE VON GENEN MIT TRANSFORMATIONSMODULIERENDER AKTIVITÄT

Title (fr)

FAMILLE DE GENES POSSEDANT UNE ACTIVITE DE MODULATION DE LA TRANSFORMATION

Publication

EP 1045926 A2 (EN)

Application

EP 98962084 A

Priority

  • US 9826433 W
  • US 6967797 P

Abstract (en)

[origin: WO9929906A2] pp32 is a member of a highly conserved family of differentiation-regulated nuclear proteins that is highly expressed in nearly all human prostatic adenocarcinomas of Gleason Grade >/=5. This contrasts with the low percentage of prostate tumors that express molecular alterations in proto-oncogenes or demonstrate tumor suppressor mutation or loss of heterozygosity. By analysis of specimens of human prostatic adenocarcinoma and paired adjacent normal prostate from three individual patients, the inventors have shown that normal prostate continues to express normal pp32, whereas three of three sets of RT-PCR-amplified transcripts from prostatic adenocarcinomas display multiple cancer-associated coding sequence changes. The cancer-associated sequence changes appear to be functionally significant. Normal pp32 exerts antineoplastic effects through suppression of transformation. In contrast, cancer-associated pp32 variants augment, rather than inhibit, transformation.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; C07K 7/08

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 14/47 (2013.01); C12Q 1/6886 (2013.01); A61K 38/00 (2013.01); C12Q 2600/136 (2013.01)

Citation (search report)

See references of WO 9929906A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9929906 A2 19990617; WO 9929906 A3 19990826; AT 330030 T 20060715; AU 1724699 A 19990628; CA 2311645 A1 19990617; DE 69834951 D1 20060727; DE 69834951 T2 20070208; EP 1045926 A2 20001025; EP 1045926 B1 20060614; JP 2002508154 A 20020319

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