EP 1045926 A2 20001025 - GENE FAMILY WITH TRANSFORMATION MODULATING ACTIVITY
Title (en)
GENE FAMILY WITH TRANSFORMATION MODULATING ACTIVITY
Title (de)
EINE FAMILIE VON GENEN MIT TRANSFORMATIONSMODULIERENDER AKTIVITÄT
Title (fr)
FAMILLE DE GENES POSSEDANT UNE ACTIVITE DE MODULATION DE LA TRANSFORMATION
Publication
Application
Priority
- US 9826433 W 19981211
- US 6967797 P 19971212
Abstract (en)
[origin: WO9929906A3] pp32 is a member of a highly conserved family of differentiation-regulated nuclear proteins that is highly expressed in nearly all human prostatic adenocarcinomas of Gleason Grade >/=5. This contrasts with the low percentage of prostate tumors that express molecular alterations in proto-oncogenes or demonstrate tumor suppressor mutation or loss of heterozygosity. By analysis of specimens of human prostatic adenocarcinoma and paired adjacent normal prostate from three individual patients, the inventors have shown that normal prostate continues to express normal pp32, whereas three of three sets of RT-PCR-amplified transcripts from prostatic adenocarcinomas display multiple cancer-associated coding sequence changes. The cancer-associated sequence changes appear to be functionally significant. Normal pp32 exerts antineoplastic effects through suppression of transformation. In contrast, cancer-associated pp32 variants augment, rather than inhibit, transformation.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6886 (2018.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/47 (2013.01); C12Q 1/6886 (2013.01); A61K 38/00 (2013.01); C12Q 2600/136 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9929906 A2 19990617; WO 9929906 A3 19990826; AT E330030 T1 20060715; AU 1724699 A 19990628; CA 2311645 A1 19990617; DE 69834951 D1 20060727; DE 69834951 T2 20070208; EP 1045926 A2 20001025; EP 1045926 B1 20060614; JP 2002508154 A 20020319
DOCDB simple family (application)
US 9826433 W 19981211; AT 98962084 T 19981211; AU 1724699 A 19981211; CA 2311645 A 19981211; DE 69834951 T 19981211; EP 98962084 A 19981211; JP 2000524477 A 19981211