Global Patent Index - EP 1047432 A1

EP 1047432 A1 2000-11-02 - DRUG-DIRECTED MUTAGENESIS/DRUG-DRIVEN SELECTION FOR LETHAL MUTANTS

Title (en)

DRUG-DIRECTED MUTAGENESIS/DRUG-DRIVEN SELECTION FOR LETHAL MUTANTS

Title (de)

ARZNEIMITTEL-GERICHTETE MUTAGENESE/ARZNEIMITTEL-GETRIEBENE SELEKTION FÜR TÖTLICHEN MUTANTEN

Title (fr)

MUTAGENESE DIRIGEE PAR LES MEDICAMENTS OU SELECTION PILOTEE PAR LES MEDICAMENTS ET CIBLANT DES MUTANTS LETAUX

Publication

EP 1047432 A1 (EN)

Application

EP 98965003 A

Priority

  • US 9827766 W
  • US 6882697 P

Abstract (en)

[origin: WO9933477A1] A series of mutations in the nucleic acids of a therapeutic target (e.g., virus such as HIV, bacteria, parasites and cancer cells) are selected for or induced by administration of a series or combination of drugs which select for drug resistant forms of the pathogen with specific mutations. In the case of patients infected with the HIV virus, a series of anti-viral drugs are administered which eventually select for a virus which is unable to replicate or is non-infectious. It is believed that the drugs cause (or select for) a series of mutations in the viral nucleic acids which code for amino acids near the active site of the HIV polymerase enzyme, thereby rendering the virus unable to replicate. Further, in the case of HIV, this can be accomplished using clinically available drugs already used to treat patients suffering from HIV infection.

IPC 1-7 (main, further and additional classification)

A61K 31/70; A61K 31/505; A61K 31/55

IPC 8 full level (invention and additional information)

A61K 31/70 (2006.01); A61K 45/06 (2006.01)

CPC (invention and additional information)

A61K 31/70 (2013.01); A61K 45/06 (2013.01)

Combination set (CPC)

  1. A61K 31/70 + A61K 31/70 + A61K 31/55
  2. A61K 31/70 + A61K 2300/00

Citation (search report)

See references of WO 9933477A1

Designated contracting state (EPC)

DE FR GB

EPO simple patent family

WO 9933477 A1 19990708; EP 1047432 A1 20001102

INPADOC legal status


2003-03-12 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020701

2000-11-02 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000614

2000-11-02 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): DE FR GB