EP 1047432 A1 20001102 - DRUG-DIRECTED MUTAGENESIS/DRUG-DRIVEN SELECTION FOR LETHAL MUTANTS
Title (en)
DRUG-DIRECTED MUTAGENESIS/DRUG-DRIVEN SELECTION FOR LETHAL MUTANTS
Title (de)
ARZNEIMITTEL-GERICHTETE MUTAGENESE/ARZNEIMITTEL-GETRIEBENE SELEKTION FÜR TÖTLICHEN MUTANTEN
Title (fr)
MUTAGENESE DIRIGEE PAR LES MEDICAMENTS OU SELECTION PILOTEE PAR LES MEDICAMENTS ET CIBLANT DES MUTANTS LETAUX
Publication
Application
Priority
- US 9827766 W 19981224
- US 6882697 P 19971224
Abstract (en)
[origin: WO9933477A1] A series of mutations in the nucleic acids of a therapeutic target (e.g., virus such as HIV, bacteria, parasites and cancer cells) are selected for or induced by administration of a series or combination of drugs which select for drug resistant forms of the pathogen with specific mutations. In the case of patients infected with the HIV virus, a series of anti-viral drugs are administered which eventually select for a virus which is unable to replicate or is non-infectious. It is believed that the drugs cause (or select for) a series of mutations in the viral nucleic acids which code for amino acids near the active site of the HIV polymerase enzyme, thereby rendering the virus unable to replicate. Further, in the case of HIV, this can be accomplished using clinically available drugs already used to treat patients suffering from HIV infection.
IPC 1-7
IPC 8 full level
A61K 31/70 (2006.01); A61K 45/06 (2006.01)
CPC (source: EP)
A61K 31/70 (2013.01); A61K 45/06 (2013.01)
Citation (search report)
See references of WO 9933477A1
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
DOCDB simple family (application)
US 9827766 W 19981224; EP 98965003 A 19981224