Global Patent Index - EP 1047457 A2

EP 1047457 A2 2000-11-02 - USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE

Title (en)

USE OF RADIOLABELED MONOCLONAL IgM IN THERAPY FOR CANCER AND AUTOIMMUNE DISEASE

Title (de)

RADIOMARKIERTE MONOKLONES IGM ZÜR THERAPIE VON KREBS UND AUTOIMMUNKRANKHEIT

Title (fr)

IMMUNOGLOBULINE M MONOCLONALE RADIOMARQUEE DESTINEE AU TRAITEMENT DU CANCER ET D'UNE MALADIE AUTO-IMMUNE

Publication

EP 1047457 A2 (EN)

Application

EP 99917293 A

Priority

  • US 9900857 W
  • US 862098 A

Abstract (en)

[origin: WO9936105A2] It has been discovered that large antibody aggregates or molecules, such as IgM or conjugated IgG or IgG fusion proteins, can be used to treat tumors by intracompartmental or intratumoral administration of anti-tumor antibody coupled to a toxin. The method can also be used in the treatment of certain disorders characterized by deposition of immune complex, for example, rheumatoid arthritis. In the preferred embodiment, the antibody is IgM and the toxin is a radioisotope, most preferably <111>In-labelled IgM or <90>Y-labelled IgM. Examples demonstrate effectiveness in mice models.

IPC 1-7 (main, further and additional classification)

A61K 51/10; A61K 31/385; A61K 47/48

IPC 8 full level (invention and additional information)

A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61K 51/00 (2006.01); A61K 51/10 (2006.01); A61P 35/00 (2006.01); A61P 37/02 (2006.01); A61K 103/32 (2006.01)

CPC (invention and additional information)

A61K 51/1096 (2013.01); A61K 47/6869 (2017.08); A61K 51/1093 (2013.01)

Citation (search report)

See references of WO 9936105A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9936105 A2 19990722; WO 9936105 A3 20000210; WO 9936105 A9 19991021; AU 3544599 A 19990802; CA 2318231 A1 19990722; EP 1047457 A2 20001102; JP 2002509122 A 20020326

INPADOC legal status


2003-09-10 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20030305

2001-06-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010503

2000-11-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000810

2000-11-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE