Global Patent Index - EP 1047662 A1

EP 1047662 A1 2000-11-02 - PURIFICATION OF TRAMADOL

Title (en)

PURIFICATION OF TRAMADOL

Title (de)

REINIGUNG VON TRAMADOL

Title (fr)

PURIFICATION DU TRAMADOL

Publication

EP 1047662 A1 (EN)

Application

EP 99901000 A

Priority

  • GB 9900013 W
  • GB 9800656 A

Abstract (en)

[origin: WO9936390A1] A process for the preparation of Tramadol according to a Grignard reaction of 2(dimethylaminomethyl)cyclo-hexanone with the reagent 3-methoxyphenylMgX, where X is a halogen, to obtain the crude base which is then introduced to a solvent, comprises contacting the crude base with hydrobromic or hydriodic acid to form a salt thereof, and subjecting the salt to a re-crystallisation step to obtain the product Tramadol hydrobromide or Tramadol hydriodide respectively, from which purified Tramadol base is obtainable for optional conversion to a pharmaceutically preferred form e.g. Tramadol hydrochloride.

IPC 1-7 (main, further and additional classification)

C07C 213/10; C07C 215/42

IPC 8 full level (invention and additional information)

C07C 213/10 (2006.01); C07C 215/42 (2006.01)

CPC (invention and additional information)

C07C 213/00 (2013.01); C07C 213/10 (2013.01); C07C 2101/14 (2013.01)

Combination set (CPC)

  1. C07C 213/00 + C07C 217/74
  2. C07C 213/10 + C07C 217/74

Citation (search report)

See references of WO 9936390A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9936390 A1 19990722; AU 2063799 A 19990802; AU 744938 B2 20020307; CA 2316991 A1 19990722; EP 1047662 A1 20001102; GB 9800656 D0 19980311; HU 0100356 A2 20020529; HU 0100356 A3 20020828; IL 136957 D0 20010614; NZ 505129 A 20011130; PL 341712 A1 20010423; SK 10352000 A3 20010212; TR 200002022 T2 20001121

INPADOC legal status


2004-08-11 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040122

2003-03-12 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030124

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: ARCHER, NICHOLAS

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: CAIRNS, STEWART

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: MITCHELL, MELVILLE

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: OGDEN, HELEN

2000-11-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000703

2000-11-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE