EP 1047662 A1 20001102 - PURIFICATION OF TRAMADOL
Title (en)
PURIFICATION OF TRAMADOL
Title (de)
REINIGUNG VON TRAMADOL
Title (fr)
PURIFICATION DU TRAMADOL
Publication
Application
Priority
- GB 9900013 W 19990114
- GB 9800656 A 19980114
Abstract (en)
[origin: WO9936390A1] A process for the preparation of Tramadol according to a Grignard reaction of 2(dimethylaminomethyl)cyclo-hexanone with the reagent 3-methoxyphenylMgX, where X is a halogen, to obtain the crude base which is then introduced to a solvent, comprises contacting the crude base with hydrobromic or hydriodic acid to form a salt thereof, and subjecting the salt to a re-crystallisation step to obtain the product Tramadol hydrobromide or Tramadol hydriodide respectively, from which purified Tramadol base is obtainable for optional conversion to a pharmaceutically preferred form e.g. Tramadol hydrochloride.
IPC 1-7
IPC 8 full level
C07C 213/10 (2006.01); C07C 215/42 (2006.01)
CPC (source: EP KR)
C07C 213/00 (2013.01 - EP); C07C 213/10 (2013.01 - EP KR); C07C 2601/14 (2017.05 - EP)
C-Set (source: EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9936390 A1 19990722; AU 2063799 A 19990802; AU 744938 B2 20020307; CA 2316991 A1 19990722; EP 1047662 A1 20001102; GB 9800656 D0 19980311; HU P0100356 A2 20020529; HU P0100356 A3 20020828; IL 136957 A0 20010614; KR 20010034010 A 20010425; NZ 505129 A 20011130; PL 341712 A1 20010423; SK 10352000 A3 20010212; TR 200002022 T2 20001121
DOCDB simple family (application)
GB 9900013 W 19990114; AU 2063799 A 19990114; CA 2316991 A 19990114; EP 99901000 A 19990114; GB 9800656 A 19980114; HU P0100356 A 19990114; IL 13695799 A 19990114; KR 20007007604 A 20000710; NZ 50512999 A 19990114; PL 34171299 A 19990114; SK 10352000 A 19990114; TR 200002022 T 19990114