EP 1047670 A1 20001102 - AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS
Title (en)
AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS
Title (de)
AMINOSULFONYLBENZAMIDDERIVATE ALS MODULATOREN DER AKTIVITÄT DER NEURONALEN CALCIUMKANÄLE
Title (fr)
DERIVES AMINOSULPHONYLBENZAMIDES UTILISES COMME INHIBITEURS DE L'ACTIVITE DES CANAUX CALCIUM NEURONAUX
Publication
Application
Priority
- GB 9900099 W 19990113
- GB 9800750 A 19980114
Abstract (en)
[origin: WO9936398A1] A pharmaceutical compound of formula (I) in which the aminosulfonyl group is attached at the 3- or 4-position, and in which R<1> is hydrogen, C1-6 Alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl or optionally substituted phenyl-C1-4 alkyl, R<2> is C1-6 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, optionally substituted phenyl-C1-4 alkyl or -(CH2)2NR<5>R<6> where R<5> and R<6> are each hydrogen or C1-6 alkyl, and R<3> and R<4> are each C1-6 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, C3-6 alkenyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl, or R<1> and R<2>, or R<3> and R<4>, or R<5> and R<6>, together with the nitrogen atom to which they are attached, form a carbocyclic group containing 4 to 7 carbon atoms optionally substituted with one to three methyl or ethyl groups and optionally containing an oxygen atom or a further nitrogen atom, said carbocyclic group being optionally fused to an optionally substituted phenyl group; or a salt thereof.
IPC 1-7
C07C 311/16; C07D 207/09; C07D 217/06; C07D 295/12; C07D 295/18; C07D 295/22; A61K 31/18
IPC 8 full level
A61K 31/18 (2006.01); A61K 31/40 (2006.01); A61K 31/445 (2006.01); A61K 31/4453 (2006.01); A61K 31/5375 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07C 311/16 (2006.01); C07D 207/09 (2006.01); C07D 211/96 (2006.01); C07D 217/06 (2006.01); C07D 295/185 (2006.01); C07D 295/22 (2006.01); C07D 295/26 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 43/00 (2017.12); C07C 311/16 (2013.01); C07D 217/06 (2013.01); C07D 295/185 (2013.01); C07D 295/26 (2013.01); C07C 2601/02 (2017.04); C07C 2601/08 (2017.04); C07C 2601/14 (2017.04)
Citation (search report)
See references of WO 9936398A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9936398 A1 19990722; AU 2172899 A 19990802; CA 2317536 A1 19990722; EP 1047670 A1 20001102; GB 9800750 D0 19980311; JP 2002509135 A 20020326
DOCDB simple family (application)
GB 9900099 W 19990113; AU 2172899 A 19990113; CA 2317536 A 19990113; EP 99901722 A 19990113; GB 9800750 A 19980114; JP 2000540115 A 19990113