Global Patent Index - EP 1047680 A2

EP 1047680 A2 2000-11-02 - BASE-CATALYZED SYNTHESIS OF 1-ARYL-4-(ARYL ETHYL)PIPERAZINES FROM AROMATIC OLEFINS AND 1-ARYL PIPERAZINES

Title (en)

BASE-CATALYZED SYNTHESIS OF 1-ARYL-4-(ARYL ETHYL)PIPERAZINES FROM AROMATIC OLEFINS AND 1-ARYL PIPERAZINES

Title (de)

BASENKATALYSIERTE SYNTHESE VON 1-ARYL-4-(ARYLETHYL)PIPERAZINEN AUS AROMATISCHEN OLEFINEN UND 1-ARYLPIPERAZINEN

Title (fr)

SYNTHESE CATALYSEE PAR BASE DE 1-ARYLE-4-(ARYLETHYL)PIPERAZINES ISSUES D'OLEFINES AROMATIQUES ET DE 1-ARYLPIPERAZINES

Publication

EP 1047680 A2 (DE)

Application

EP 98966378 A

Priority

  • DE 19801597 A
  • EP 9808344 W

Abstract (en)

[origin: DE19801597A1] 1-Aryl-4-(arylethyl)piperazine derivatives (I) are prepared by base catalyzed reaction of 1-arylpiperazine derivatives (II) and aromatic olefins (III). Preparation of 1-aryl-4-(arylethyl)piperazine derivatives of formula (I) comprises reaction of a 1-arylpiperazine derivative of formula (II) and an aromatic olefin of formula Ar'CR1=CHR2 (III) in an inert solvent using one or more basic catalysts. Ar, Ar' = optionally fused 6-22C aromatic group or optionally fused 5-22C heteroaromatic group containing at least one ring N, O or S heteroatom; R1, R2 = H, 1-8C alkyl or Ar.

IPC 1-7 (main, further and additional classification)

C07D 295/02; C07D 295/06; C07D 295/08

IPC 8 full level (invention and additional information)

C07D 295/02 (2006.01); C07B 61/00 (2006.01); C07D 295/023 (2006.01); C07D 295/06 (2006.01); C07D 295/073 (2006.01); C07D 295/08 (2006.01); C07D 295/096 (2006.01)

CPC (invention and additional information)

C07D 295/023 (2013.01); C07D 295/073 (2013.01); C07D 295/096 (2013.01)

Citation (search report)

See references of WO 9936412A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19801597 A1 19990729; DE 19801597 C2 20010503; EP 1047680 A2 20001102; JP 2002509141 A 20020326; US 6313297 B1 20011106; WO 9936412 A2 19990722; WO 9936412 A3 19990916

INPADOC legal status


2004-01-07 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030701

2000-11-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000817

2000-11-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE