EP 1047768 A1 20001102 - A METHOD OF FERMENTATION PREPARATION OF LOVASTATIN BY AN $i(ASPERGILLUS TERREUS) STRAIN AND THE STRAIN FOR PERFORMING THE METHOD
Title (en)
A METHOD OF FERMENTATION PREPARATION OF LOVASTATIN BY AN $i(ASPERGILLUS TERREUS) STRAIN AND THE STRAIN FOR PERFORMING THE METHOD
Title (de)
VERFAHREN ZUR FERMENTATIVEN HERSTELLUNG VON LOVASTATIN MITTELS EINES ASPERGILLUS TERREUS STAMMES, SOWIE DER STAMM ZUR DURCHFÜHRUNG DES VERFAHRENS
Title (fr)
PROCEDE DE PREPARATION PAR FERMENTATION DE LOVASTINE A L'AIDE D'UNE SOUCHE D'$i(ASPERGILLUS TERREUS) ET SOUCHE UTILISEE POUR METTRE EN OEUVRE LE PROCEDE
Publication
Application
Priority
- SK 9800014 W 19981012
- SK 139597 A 19971013
Abstract (en)
[origin: WO9919458A1] The new strain Aspergillus terreus CCM 8236 was obtained by means of classic mutagenesis procedures. The process of aerobic fermentation of lovastatin by the strain of Aspergillus terreus CCM 8236 in the form of acid in a submersion culture in a laboratory scale is described. The inoculum was prepared in a broth having low pH value. The mixture of glucose and lactose (at the ratio of 1:22) at the high concentration and Pharmamedia is used as the carbon and nitrogen source, respectively. The strain produced more than 2000 mg/l of lovastatin during 170 hours in the above-mentioned broth.
IPC 1-7
IPC 8 full level
C12P 7/62 (2006.01); C12P 17/06 (2006.01)
CPC (source: EP)
C12N 1/145 (2021.05); C12P 7/62 (2013.01); C12P 17/06 (2013.01); C12R 2001/66 (2021.05)
Citation (search report)
See references of WO 9919458A1
Designated contracting state (EPC)
DE ES PT
DOCDB simple family (publication)
WO 9919458 A1 19990422; EP 1047768 A1 20001102; SK 139597 A3 19981104; SK 281320 B6 20010212; TR 200000996 T2 20001221
DOCDB simple family (application)
SK 9800014 W 19981012; EP 98948055 A 19981012; SK 139597 A 19971013; TR 200000996 T 19981012