Global Patent Index - EP 1047768 A1

EP 1047768 A1 2000-11-02 - A METHOD OF FERMENTATION PREPARATION OF LOVASTATIN BY AN $i(ASPERGILLUS TERREUS) STRAIN AND THE STRAIN FOR PERFORMING THE METHOD

Title (en)

A METHOD OF FERMENTATION PREPARATION OF LOVASTATIN BY AN $i(ASPERGILLUS TERREUS) STRAIN AND THE STRAIN FOR PERFORMING THE METHOD

Title (de)

VERFAHREN ZUR FERMENTATIVEN HERSTELLUNG VON LOVASTATIN MITTELS EINES ASPERGILLUS TERREUS STAMMES, SOWIE DER STAMM ZUR DURCHFÜHRUNG DES VERFAHRENS

Title (fr)

PROCEDE DE PREPARATION PAR FERMENTATION DE LOVASTINE A L'AIDE D'UNE SOUCHE D'$i(ASPERGILLUS TERREUS) ET SOUCHE UTILISEE POUR METTRE EN OEUVRE LE PROCEDE

Publication

EP 1047768 A1 (EN)

Application

EP 98948055 A

Priority

  • SK 9800014 W
  • SK 139597 A

Abstract (en)

[origin: WO9919458A1] The new strain Aspergillus terreus CCM 8236 was obtained by means of classic mutagenesis procedures. The process of aerobic fermentation of lovastatin by the strain of Aspergillus terreus CCM 8236 in the form of acid in a submersion culture in a laboratory scale is described. The inoculum was prepared in a broth having low pH value. The mixture of glucose and lactose (at the ratio of 1:22) at the high concentration and Pharmamedia is used as the carbon and nitrogen source, respectively. The strain produced more than 2000 mg/l of lovastatin during 170 hours in the above-mentioned broth.

IPC 1-7 (main, further and additional classification)

C12N 1/14; C12P 7/42; C12P 7/62; C12P 17/06

IPC 8 full level (invention and additional information)

C12P 7/62 (2006.01); C12P 17/06 (2006.01)

CPC (invention and additional information)

C12R 1/66 (2013.01); C12P 7/62 (2013.01); C12P 17/06 (2013.01)

Citation (search report)

See references of WO 9919458A1

Designated contracting state (EPC)

DE ES PT

EPO simple patent family

WO 9919458 A1 19990422; EP 1047768 A1 20001102; SK 139597 A3 19981104; SK 281320 B6 20010212; TR 200000996 T2 20001221

INPADOC legal status


2004-12-01 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040501

2001-02-14 [RTI1] TITLE (CORRECTION)

- Free text: A METHOD OF FERMENTATION PREPARATION OF LOVASTATIN BY AN (ASPERGILLUS TERREUS) STRAIN AND THE STRAIN FOR PERFORMING THE METHOD

2000-11-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000405

2000-11-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): DE ES PT