Global Patent Index - EP 1047938 A2

EP 1047938 A2 2000-11-02 - IDENTIFICATION OF SUBSTANCES THAT MODIFY CELLULAR SECRETORY FUNCTION

Title (en)

IDENTIFICATION OF SUBSTANCES THAT MODIFY CELLULAR SECRETORY FUNCTION

Title (de)

IDENTIFIZIERUNG VON SUBSTANZEN, DIE DIE SEKRETION VON ZELLEN BEEINFLUSSEN

Title (fr)

LIGNEES CELLULAIRES RECOMBINEES POUR LE CRIBLAGE DE MEDICAMENTS

Publication

EP 1047938 A2 (EN)

Application

EP 99901421 A

Priority

  • US 9900551 W
  • US 7119398 P
  • US 7120998 P
  • US 7255698 P
  • US 8782198 P
  • US 8784898 P

Abstract (en)

[origin: WO9935255A2] The present invention provides compositions and methods of comprising engineered human neuroendocrine cell lines having a regulated secretory pathway. More particularly, the present invention provdes methods and compositions for engineering regulated secretion into cells. Certain aspects of the invention provide glycemic sensing mechanisms to a population of genetically engineered cells. In particular embodiments, the present invention provides compositions and methods of providing indirect glycemic sensing mechanisms to a population of genetically engineered cells. Specifically contemplated are methods and compositions for engineering indirect glucose sensing and glucose counter regulation capacity into cells. Methods of using these cells for minimizing hypoglycemia in diabetic therapy are also disclosed.

IPC 1-7 (main, further and additional classification)

G01N 33/50; C12N 5/10; G01N 33/74

IPC 8 full level (invention and additional information)

A61K 48/00 (2006.01); G01N 33/50 (2006.01); A61K 35/12 (2006.01)

CPC (invention and additional information)

G01N 33/5058 (2013.01); A61K 48/00 (2013.01); C12N 5/0037 (2013.01); C12N 5/0676 (2013.01); G01N 33/5008 (2013.01); G01N 33/502 (2013.01); G01N 33/5044 (2013.01); G01N 33/507 (2013.01); A61K 35/12 (2013.01); C12N 2500/20 (2013.01); C12N 2500/22 (2013.01); C12N 2500/24 (2013.01); C12N 2500/32 (2013.01); C12N 2500/38 (2013.01); C12N 2500/40 (2013.01); C12N 2500/46 (2013.01); C12N 2500/90 (2013.01); C12N 2510/02 (2013.01); C12N 2533/74 (2013.01)

Citation (search report)

See references of WO 9935495A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9935255 A2 19990715; WO 9935255 A3 19991028; WO 9935255 A8 19990910; WO 9935255 A9 20010531; AU 2112199 A 19990726; AU 2113199 A 19990726; AU 2455199 A 19990726; CA 2318376 A1 19990715; CA 2318379 A1 19990715; EP 1045898 A2 20001025; EP 1047938 A2 20001102; WO 9935242 A1 19990715; WO 9935242 A9 19990930; WO 9935495 A2 19990715; WO 9935495 A3 19991125

INPADOC legal status


2003-02-05 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020801

2000-11-02 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000727

2000-11-02 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-11-02 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000727;LT PAYMENT 20000727;LV PAYMENT 20000727;MK PAYMENT 20000727;RO PAYMENT 20000727;SI PAYMENT 20000727