Global Patent Index - EP 1049667 A1

EP 1049667 A1 2000-11-08 - NOVEL NAPHTHYL SUBSTITUTED AND HETEROCYCLIC SUBSTITUTED SULFONAMIDES

Title (en)

NOVEL NAPHTHYL SUBSTITUTED AND HETEROCYCLIC SUBSTITUTED SULFONAMIDES

Title (de)

NEUE NAPHTHYL- UND HEREOCYCLISCH-SUBSTITUIERTE SULFONAMIDE

Title (fr)

NOUVEAUX SULFONAMIDES A SUBSTITUTION NAPHTYLE ET HETEROCYCLIQUE

Publication

EP 1049667 A1 (DE)

Application

EP 99932444 A

Priority

  • DE 19802436 A
  • EP 9900134 W

Abstract (en)

[origin: DE19802436A1] N-phenyl-, naphthyl- or heterocyclyl- benzenesulfonamides, their stereoisomeric mixtures and salts. N-phenyl-, naphthyl- or heterocyclyl benzenesulfonamides, of formula (I), their stereoisomeric mixtures and salts are new. A = residue of formula (i)-(iv) G = hydrogen, halo, nitro, carboxy, cyano, hydroxy, 1-6C linear or branched alkyl, alkoxy or alkoxycarbonyl, benzyloxy, (CH2)aNR<3>R<4>, SO2NR<3>'R<4>', OSO2R<5> or phenylaminosulfonyl, ring-substituted by -NHCOR<2>'; a = 1-4; R<3>, R<3>', R<4> and R<4>' = hydrogen, phenyl or 1-6C linear or branched alkyl or acyl; R<5> = 1-5C linear or branched alkyl, or benzyl or phenyl (these optionally substituted by 1 or 2 of halo, nitro, cyano, trifluoromethyl, trifluoromethoxy or 1-4C linear or branched alkyl); R<1> = hydrogen or 1-3C linear or branched alkyl; D, E, L or M = hydrogen, halo, nitro, cyano, hydroxy, carboxy, dimethylaminosulfonyl, trifluoromethyl, trifluoromethoxy, or 1-5C linear or branched alkyl, alkoxy or alkoxycarbonyl; R<2> and R<2>' = adamantyl, 2-6C linear or branched alkenyl, 3-6C cycloalkyl (optionally substituted by halo),1-9C linear or branched alkyl (optionally substituted by 1-3 of 1-6C alkoxy, hydroxy, cyano, azido, halo, nitro, amino, trifluoromethyl or phenyl (itself optionally substituted by nitro, halo, hydroxy or 1-4C linear or branched alkyl or alkoxy)) and/or alkyl optionally substituted by -OCOR<6>; R<6> = 1-5C linear or branched alkyl optionally substituted by carboxy; or R<2> and/or R<2>' is 5-ethyl-1,3-dioxan-5-yl or 3-ethyl-oxetan-3-yl. Independent claims are also included for the following: (1) methods for preparation of (I); and (2) pharmaceutical compositions containing (I).

IPC 1-7 (main, further and additional classification)

C07C 311/44; A61K 31/18; C07C 311/46; C07D 233/26; C07D 319/06

IPC 8 full level (invention and additional information)

A61K 31/167 (2006.01); A61K 31/18 (2006.01); A61K 31/215 (2006.01); A61K 31/277 (2006.01); A61K 31/337 (2006.01); A61K 31/357 (2006.01); A61K 31/39 (2006.01); A61K 31/4245 (2006.01); A61K 31/433 (2006.01); A61P 31/12 (2006.01); C07C 311/21 (2006.01); C07C 311/29 (2006.01); C07C 311/37 (2006.01); C07C 311/44 (2006.01); C07C 311/46 (2006.01); C07D 271/04 (2006.01); C07D 271/12 (2006.01); C07D 285/14 (2006.01); C07D 305/08 (2006.01); C07D 319/06 (2006.01); C07D 327/04 (2006.01)

CPC (invention and additional information)

C07C 311/21 (2013.01); C07C 311/29 (2013.01); C07C 311/37 (2013.01); C07D 271/12 (2013.01); C07D 305/08 (2013.01); C07D 319/06 (2013.01); C07C 2101/02 (2013.01); C07C 2101/14 (2013.01); C07C 2103/74 (2013.01)

Citation (search report)

See references of WO 9937608A1

Designated contracting state (EPC)

DE ES FR GB IT

EPO simple patent family

DE 19802436 A1 19990729; AU 3248899 A 19990809; EP 1049667 A1 20001108; JP 2002501042 A 20020115; WO 9937608 A1 19990729

INPADOC legal status


2003-01-02 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020618

2002-03-27 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020207

2000-11-08 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000823

2000-11-08 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): DE ES FR GB IT