Global Patent Index - EP 1049677 A1

EP 1049677 A1 2000-11-08 - NOVEL SULFONAMIDE DERIVATIVES AS INHIBITORS OF BONE RESORPTION AND AS INHIBITORS OF CELL ADHESION

Title (en)

NOVEL SULFONAMIDE DERIVATIVES AS INHIBITORS OF BONE RESORPTION AND AS INHIBITORS OF CELL ADHESION

Title (de)

SULFONAMIDE DERIVATE ALS KNOCHENRESORPTION INHIBITOREN UND ALS ZELLADHÄSION INHIBITOREN

Title (fr)

NOUVEAUX DERIVES DE SULFAMIDE COMME INHIBITEURS DE LA RESORPTION OSSEUSE ET COMME INHIBITEURS DE L'ADHERENCE CELLULAIRE

Publication

EP 1049677 A1 (EN)

Application

EP 99904789 A

Priority

  • EP 9900242 W
  • US 1248998 A

Abstract (en)

[origin: WO9937621A1] The present invention relates to sulfonamide derivatives of formula (I), in which R<1>, R<2>, R<4>, R<5> and R<6> have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of the formula (I) are valuable pharmaceutical active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and inhibit bone resorption by osteoclasts. They are suitable, for example, for the therapy and prophylaxis of diseases which are caused at least partially by an undesired extent of bone resorption, for example of osteoporosis. The invention furthermore relates to processes for the preparation of compounds of the formula (I), their use, in particular as pharmaceutical active ingredients, and pharmaceutical preparations comprising them.

IPC 1-7 (main, further and additional classification)

C07D 239/16; A61K 31/505; C07C 311/19

IPC 8 full level (invention and additional information)

A61K 31/197 (2006.01); A61K 31/505 (2006.01); A61K 31/506 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 19/10 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07C 311/19 (2006.01); C07D 239/16 (2006.01); C07D 401/12 (2006.01); C07D 409/12 (2006.01)

CPC (invention and additional information)

C07C 311/19 (2013.01); C07D 239/16 (2013.01)

Citation (search report)

See references of WO 9937621A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9937621 A1 19990729; AP 1269 A 20040403; AP 200001863 D0 20000930; AR 014456 A1 20010228; AU 2518199 A 19990809; AU 752882 B2 20021003; BG 104630 A 20010430; BR 9907735 A 20001017; CA 2318221 A1 19990729; CN 1177832 C 20041201; CN 1293662 A 20010502; EA 003102 B1 20021226; EA 200000785 A1 20010226; EP 1049677 A1 20001108; HR P20000493 A2 20010630; HU 0100520 A2 20010730; HU 0100520 A3 20021128; ID 26219 A 20001207; IL 137423 D0 20010724; JP 2002501054 A 20020115; NO 20003765 A 20000925; NO 20003765 D0 20000721; NO 318795 B1 20050509; NZ 505613 A 20021126; PL 341871 A1 20010507; SK 10632000 A3 20010212; TR 200002160 T2 20010723; TW I247742 B 20060121; UA 63990 C2 20001115; YU 47200 A 20021115; ZA 9900476 B 19990805

INPADOC legal status


2009-08-05 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20090213

2004-06-23 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040507

2000-11-08 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000823

2000-11-08 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-11-08 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000823;LT PAYMENT 20000823;LV PAYMENT 20000823;MK PAYMENT 20000823;RO PAYMENT 20000823;SI PAYMENT 20000823