EP 1049692 A1 20001108 - NOVEL BICYCLENE-SUBSTITUTED OXAZOLIDINONES
Title (en)
NOVEL BICYCLENE-SUBSTITUTED OXAZOLIDINONES
Title (de)
NEUE MIT BICYCLEN SUBSTITUIERTE OXAZOLIDINONE
Title (fr)
NOUVELLES OXAZOLIDINONES A SUBSTITUTION BICYCLENE
Publication
Application
Priority
- DE 19802239 A 19980122
- EP 9900096 W 19990109
Abstract (en)
[origin: DE19802239A1] 3-Heterocyclyl-5-(substituted methyl)-2-oxazolidinone derivatives (I) are new. 3-Heterocyclyl-5-(substituted methyl)-2-oxazolidinone derivatives of formula (I) and their stereosiomers and salts are new: A = a bi- or tricyclic heterocyclic group of formula (i), (ii) or (iii): D, D', D = H, COOH, halogen, CN, CHO, CF3, NO2 or 1-6C alkoxy, alkoxycarbonyl, alkylthio, acyl or alkyl; E, E' = CH2, O, S, SO or SO2; L = O, S or NR13; R<13> = H, phenyl, OH or 1-6C alkoxy; R<2>-R<5>, R<7>-R<10> = H, or 1-6C alkyl or 2-6C alkenyl optionally substituted by Ar<1>; or R<2>+R<3>, R<4>+R<5>, R<7>+R<8> and/or R<9>+R<10> = O, CH2 or CHR<14>; Ar<1> = 6-10C aryl or 5- or 6-membered heteroaryl (containing 1-3 heteroatoms selected from S, N and O) optionally substituted by 1-6C alkoxy, 1-6C alkyl, OH or halogen; R<14> = 6-10C aryl or 5- to 7-membered heteroaryl (containing 1-3 heteroatoms selected from S, N and O) optionally substituted by 1-6C alkoxy, 1-6C alkyl, OH or halogen; R<6>, R<11>, R<12> = H, 1-6C alkyl, 2-6C alkoxycarbonyl or COR<15>; R<15> = 6-10C aryl, 5- to 7-membered heteroaryl (containing 1-3 heteroatoms selected from S, N and O), 1-4C alkyl or (6-10C)aryl(1-4C)alkyl, where (hetero)aryl is optionally substituted by halogen, CF3, NO2, OH, 1-6C alkyl and/or 1-6C alkoxy; R<1> = N3, OR<16>, OSO2R<17> or NHR<19>; R<16> = H or 1-6C acyl; R<17> = 1-6C alkyl or phenyl; R<19> = H, C(Q)R<20> or P(O)(OR<21>)(OR<22>); Q = O or S; R<20> = 1-8C alkoxy or CF3; 3-6C cycloalkyl optionally substituted by halogen or 6-10C aryl; 6-10C aryl or 5- or 6-membered heterocyclyl (containing 1-3 heteroatoms selected from S, N and O) optionally substituted by 1-2 of halogen, CN, NO2, OH and phenyl; 1-6C alkyl optionally substituted by phenoxy, benzyloxy, COOH, halogen 2-6C alkoxycarbonyl, 1-6C acyl or 5- or 6-membered S-, N- and/or O-containing heterocyclyl; or NR<23>R<24>; R<23>, R<24> = H, phenyl, pyridyl, 1-5C alkyl or morpholino(1-5C)alkyl; R<21>, R<22> = H or 1-4C alkyl.
IPC 1-7
C07D 413/04; C07D 498/06; C07D 417/04; A61K 31/535; A61K 31/54; A61K 31/47; C07D 413/14; C07D 417/14
IPC 8 full level
A61K 31/4709 (2006.01); A61K 31/517 (2006.01); A61K 31/538 (2006.01); A61K 31/5383 (2006.01); A61K 31/5415 (2006.01); A61P 31/04 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 498/06 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01)
Citation (search report)
See references of WO 9937641A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19802239 A1 19990729; AU 2616199 A 19990809; EP 1049692 A1 20001108; JP 2002501065 A 20020115; WO 9937641 A1 19990729
DOCDB simple family (application)
DE 19802239 A 19980122; AU 2616199 A 19990109; EP 9900096 W 19990109; EP 99906112 A 19990109; JP 2000528563 A 19990109