Global Patent Index - EP 1049692 A1

EP 1049692 A1 2000-11-08 - NOVEL BICYCLENE-SUBSTITUTED OXAZOLIDINONES

Title (en)

NOVEL BICYCLENE-SUBSTITUTED OXAZOLIDINONES

Title (de)

NEUE MIT BICYCLEN SUBSTITUIERTE OXAZOLIDINONE

Title (fr)

NOUVELLES OXAZOLIDINONES A SUBSTITUTION BICYCLENE

Publication

EP 1049692 A1 (DE)

Application

EP 99906112 A

Priority

  • DE 19802239 A
  • EP 9900096 W

Abstract (en)

[origin: DE19802239A1] 3-Heterocyclyl-5-(substituted methyl)-2-oxazolidinone derivatives (I) are new. 3-Heterocyclyl-5-(substituted methyl)-2-oxazolidinone derivatives of formula (I) and their stereosiomers and salts are new: A = a bi- or tricyclic heterocyclic group of formula (i), (ii) or (iii): D, D', D = H, COOH, halogen, CN, CHO, CF3, NO2 or 1-6C alkoxy, alkoxycarbonyl, alkylthio, acyl or alkyl; E, E' = CH2, O, S, SO or SO2; L = O, S or NR13; R<13> = H, phenyl, OH or 1-6C alkoxy; R<2>-R<5>, R<7>-R<10> = H, or 1-6C alkyl or 2-6C alkenyl optionally substituted by Ar<1>; or R<2>+R<3>, R<4>+R<5>, R<7>+R<8> and/or R<9>+R<10> = O, CH2 or CHR<14>; Ar<1> = 6-10C aryl or 5- or 6-membered heteroaryl (containing 1-3 heteroatoms selected from S, N and O) optionally substituted by 1-6C alkoxy, 1-6C alkyl, OH or halogen; R<14> = 6-10C aryl or 5- to 7-membered heteroaryl (containing 1-3 heteroatoms selected from S, N and O) optionally substituted by 1-6C alkoxy, 1-6C alkyl, OH or halogen; R<6>, R<11>, R<12> = H, 1-6C alkyl, 2-6C alkoxycarbonyl or COR<15>; R<15> = 6-10C aryl, 5- to 7-membered heteroaryl (containing 1-3 heteroatoms selected from S, N and O), 1-4C alkyl or (6-10C)aryl(1-4C)alkyl, where (hetero)aryl is optionally substituted by halogen, CF3, NO2, OH, 1-6C alkyl and/or 1-6C alkoxy; R<1> = N3, OR<16>, OSO2R<17> or NHR<19>; R<16> = H or 1-6C acyl; R<17> = 1-6C alkyl or phenyl; R<19> = H, C(Q)R<20> or P(O)(OR<21>)(OR<22>); Q = O or S; R<20> = 1-8C alkoxy or CF3; 3-6C cycloalkyl optionally substituted by halogen or 6-10C aryl; 6-10C aryl or 5- or 6-membered heterocyclyl (containing 1-3 heteroatoms selected from S, N and O) optionally substituted by 1-2 of halogen, CN, NO2, OH and phenyl; 1-6C alkyl optionally substituted by phenoxy, benzyloxy, COOH, halogen 2-6C alkoxycarbonyl, 1-6C acyl or 5- or 6-membered S-, N- and/or O-containing heterocyclyl; or NR<23>R<24>; R<23>, R<24> = H, phenyl, pyridyl, 1-5C alkyl or morpholino(1-5C)alkyl; R<21>, R<22> = H or 1-4C alkyl.

IPC 1-7 (main, further and additional classification)

C07D 413/04; A61K 31/47; A61K 31/535; A61K 31/54; C07D 413/14; C07D 417/04; C07D 417/14; C07D 498/06

IPC 8 full level (invention and additional information)

A61K 31/4709 (2006.01); A61K 31/517 (2006.01); A61K 31/538 (2006.01); A61K 31/5383 (2006.01); A61K 31/5415 (2006.01); A61P 31/04 (2006.01); C07D 413/04 (2006.01); C07D 413/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 498/06 (2006.01)

CPC (invention and additional information)

C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01)

Citation (search report)

See references of WO 9937641A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19802239 A1 19990729; AU 2616199 A 19990809; EP 1049692 A1 20001108; JP 2002501065 A 20020115; WO 9937641 A1 19990729

INPADOC legal status


2003-01-08 [18W] WITHDRAWN

- Date of withdrawal: 20021119

2002-10-23 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020904

2000-11-08 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000822

2000-11-08 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE