Global Patent Index - EP 1049701 A1

EP 1049701 A1 2000-11-08 - TRICYCLIC INDOLENE SUBSTITUTED OXAZOLIDINONES

Title (en)

TRICYCLIC INDOLENE SUBSTITUTED OXAZOLIDINONES

Title (de)

MIT TRICYCLISCHEN INDOLEN SUBSTITUIERTE OXAZOLIDINONE

Title (fr)

OXAZOLIDINONES SUBSTITUEES AVEC DES INDOLES TRICYCLIQUES

Publication

EP 1049701 A1 (DE)

Application

EP 99903616 A

Priority

  • DE 19802235 A
  • EP 9900097 W

Abstract (en)

[origin: DE19802235A1] 3-Indolyl-2-oxazolidinone derivatives (I) are new. 3-Indolyl-2-oxazolidinone derivatives of formula (I) and their stereoisomers and salts are new: A+D = a group of formula (i) or (ii): L, L' = O or NR13; R13 = H, COOH, 3-6C cyloalkyl or 2-6C alkoxycarbonyl; 1-6C acyl optionally substituted by halogen, OH, 1-5C alkoxy or NR14R15; 1-6C alkyl or 2-6C alkenyl optionally substituted by CN, halogen, COOH, 2-5C alkoxycarbony or NR14'R15' and/or by Ar; R14, R15, R14', R15' = H, phenyl or 1-5C alkyl; Ar = 6-14C aryl optionally substituted by halogen or 1-6C alkyl, alkoxy or acyl; R3-R6 = H, 1-6C alkyl or 1-6C haloalkyl, or R3+R4 and.or R5+R6 = O or S; R7-R12 = H or 1-6C alkyl optionally substituted by OH, halogen, 1-6C alkoxy, 2-6C alkoxycarbonyl, 6-10C aryl or NR16R17, or R7+R8, R9+R10 and/or R11+R12 = O or S, or R10+R11 = a bond; R16, R17 = H, phenyl or 1-5C alkyl; R1 = N3, OR18, OSO2R19 or NR20R21; R18 = H or 1-6C acyl; R19 = 1-6C alkyl or phenyl; R20 = H; R21 = H, C(Q)R22 or P(O)(OR23)(OR24); Q = O or S; R22 = 1-8C alkoxy or CF3; 3-6C cycloalkyl optionally substituted by halogen or 6-10C aryl; 6-10C aryl or 5- or 6-membered saturated or aromatic heterocyclyl containing 1-3 heteroatoms selected from S, N and O, where aryl and heterocyclyl are optionally substituted by 1-2 of halogen, CN, NO2, OH or phenyl; 1-6C alkyl optionally substituted by phenoxy, benzyloxy, COOH, halogen, 2-6C alkoxycarbonyl, 1-6C acyl or 5- or 6-membered heterocyclyl containing S, N and/or O; or NR25R26; R25, R26 = H, phenyl, pyridyl, 1-5C alkyl or morpholino(1-5C)alkyl; R23, R24 = H or 1-4C alkyl; R2 = H, halogen or 1-4C alkyl; E = H or halogen.

IPC 1-7 (main, further and additional classification)

C07D 498/04; A61K 31/42; A61K 31/495; A61K 31/535; C07D 487/04

IPC 8 full level (invention and additional information)

A61K 31/422 (2006.01); A61K 31/4985 (2006.01); A61K 31/5383 (2006.01); A61P 31/04 (2006.01); C07D 487/04 (2006.01); C07D 498/04 (2006.01)

CPC (invention and additional information)

C07D 487/04 (2013.01)

Citation (search report)

See references of WO 9937652A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19802235 A1 19990729; AU 2420699 A 19990809; EP 1049701 A1 20001108; JP 2002501073 A 20020115; WO 9937652 A1 19990729

INPADOC legal status


2003-01-08 [18W] WITHDRAWN

- Date of withdrawal: 20021119

2002-06-12 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020430

2000-11-08 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000822

2000-11-08 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE