Global patent index - EP 1049715 A2

EP 1049715 A2 2000-11-08 - RHO FAMILY ANTAGONISTS AND THEIR USE TO BLOCK INHIBITION OF NEURITE OUTGROWTH

Title (en)

RHO FAMILY ANTAGONISTS AND THEIR USE TO BLOCK INHIBITION OF NEURITE OUTGROWTH

Title (de)

ANTAGONISTEN DER RHOPROTEIN FAMILIE UND IHRE VERWENDUNG ZUM BLOCKIEREN DER INHIBIERUNG DES NEURITENWACHSTUM

Title (fr)

ANTAGONISTES DE LA FAMILLE RHO ET LEUR UTILISATION POUR BLOQUER L'INHIBITION DE L'EXCROISSANCE DES NEURITES

Publication

EP 1049715 A2 (EN)

Application

EP 98951138 A

Priority

  • CA 9801013 W
  • CA 2214841 A

Abstract (en)

[origin: WO9923113A2] This invention provides for the use of antagonists of Rho, or proteins related to Rho as therapeutic targets for agents designed to block growth inhibition by myelin or myelin proteins. One embodiment pertains to the use of Rho antagonists that foster axon regeneration in the central nervous system. The therapeutic agent or antagonist can be small molecules, proteins or peptides, or any agent that binds to Rho or its family members to inactivate this patheway. Embodiments include: the use of the Rho regulatory pathway as a target for Rho antagonists; the use of GDP dissociation inhibitors (GDIs) inhibit the dissociation of GDP from Rho, and thereby prevent the binding of GTP necessary for the activation of Rho; the use of Rho specific GTPase activating protein (GAPs) as targets for the regulation of Rho activity; the use of agents that promote Rho binding to GDI, and block Rho binding to the plasma membrane are also considered within the scope of this invention; the use of C3 transferase and related toxins such as A and B, with related Rho-inhibitory activity to inactivate Rho and stimulate axon growth; the use of dominant negative forms of Rho, used to inactivate Rho, to foster axon growth.

IPC 1-7 (main, further and additional classification)

C07K 14/47; A61K 31/44

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01); C12N 9/10 (2006.01); C12N 9/16 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 9/16 (2013.01); C07K 14/4722 (2013.01); C12N 9/1077 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9923113A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9923113 A2 19990514; WO 9923113 A3 19990826; AU 9732198 A 19990524; CA 2214841 A1 19990430; CA 2304981 A1 19990514; EP 1049715 A2 20001108

INPADOC legal status

2004-10-13 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20040414

2004-01-14 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20031201

2002-09-11 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: UNIVERSITE DE MONTREAL

- Ref Legal Event Code: RAP1

2002-09-11 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: MCKERRACHER, LISA

2002-09-11 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: LEHMANN, MAXIME

2000-11-08 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000817

2000-11-08 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE