Global Patent Index - EP 1049789 A1

EP 1049789 A1 20001108 - AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT

Title (en)

AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT

Title (de)

SELBSTREGULIERTES SYSTEM ZUM TESTEN VON MIKROBIELLEN GENEN, WELCHE EIN MÖGLICHES ZIEL VON ANTIMIKROBIELLEN STOFFEN SIND, UNTER VERWENDUNG VON EINEM DURCH TETRAZYKLIN-REGULIERTEM ELEMENT

Title (fr)

SYSTEME AUTOREGULATEUR DE VALIDATION DE GENES MICROBIENS EN TANT QU'EVENTUELLES CIBLES ANTIMICROBIENNES UTILISANT UN ELEMENT REGULABLE PAR LA TETRACYCLINE

Publication

EP 1049789 A1 20001108 (EN)

Application

EP 99903005 A 19990112

Priority

  • US 9900371 W 19990112
  • US 7164098 P 19980116

Abstract (en)

[origin: WO9936554A1] A screen has been designed to genetically engineer microbial pathogens so that expression of specific genes can be regulated in vitro and during host infection to facilitate the identification of bacterial genes essential for maintaining an infection. Specifically, gene regulatory elements which respond to the presence or absence of tetracycline are used to regulate the expression of endogenous bacterial genes. Because tetracycline is not normally present in animals, a tetracycline-regulated microbial gene can be controlled in vivo by adding or removing tetracycline from the infected animals' diet.

IPC 1-7

C12N 15/63; C12N 15/90; C12Q 1/68; C12Q 1/04

IPC 8 full level

C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/63 (2006.01); C12N 15/90 (2006.01); C12Q 1/04 (2006.01); C12Q 1/68 (2006.01); C12R 1/445 (2006.01)

CPC (source: EP)

C12N 15/1034 (2013.01); C12N 15/635 (2013.01); C12N 15/90 (2013.01)

Citation (search report)

See references of WO 9936554A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9936554 A1 19990722; AU 2312699 A 19990802; EP 1049789 A1 20001108; JP 2002508972 A 20020326

DOCDB simple family (application)

US 9900371 W 19990112; AU 2312699 A 19990112; EP 99903005 A 19990112; JP 2000540255 A 19990112