Global Patent Index - EP 1049789 A1

EP 1049789 A1 2000-11-08 - AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT

Title (en)

AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT

Title (de)

SELBSTREGULIERTES SYSTEM ZUM TESTEN VON MIKROBIELLEN GENEN, WELCHE EIN MÖGLICHES ZIEL VON ANTIMIKROBIELLEN STOFFEN SIND, UNTER VERWENDUNG VON EINEM DURCH TETRAZYKLIN-REGULIERTEM ELEMENT

Title (fr)

SYSTEME AUTOREGULATEUR DE VALIDATION DE GENES MICROBIENS EN TANT QU'EVENTUELLES CIBLES ANTIMICROBIENNES UTILISANT UN ELEMENT REGULABLE PAR LA TETRACYCLINE

Publication

EP 1049789 A1 (EN)

Application

EP 99903005 A

Priority

  • US 9900371 W
  • US 7164098 P

Abstract (en)

[origin: WO9936554A1] A screen has been designed to genetically engineer microbial pathogens so that expression of specific genes can be regulated in vitro and during host infection to facilitate the identification of bacterial genes essential for maintaining an infection. Specifically, gene regulatory elements which respond to the presence or absence of tetracycline are used to regulate the expression of endogenous bacterial genes. Because tetracycline is not normally present in animals, a tetracycline-regulated microbial gene can be controlled in vivo by adding or removing tetracycline from the infected animals' diet.

IPC 1-7 (main, further and additional classification)

C12N 15/63; C12N 15/90; C12Q 1/04; C12Q 1/68

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/10 (2006.01); C12N 15/63 (2006.01); C12N 15/90 (2006.01); C12Q 1/04 (2006.01); C12Q 1/68 (2006.01); C12R 1/445 (2006.01)

CPC (invention and additional information)

C12N 15/1034 (2013.01); C12N 15/635 (2013.01); C12N 15/90 (2013.01)

Citation (search report)

See references of WO 9936554A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9936554 A1 19990722; AU 2312699 A 19990802; EP 1049789 A1 20001108; JP 2002508972 A 20020326

INPADOC legal status


2006-05-31 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051112

2005-05-04 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: PHARMACIA & UPJOHN COMPANY LLC

2004-01-21 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031203

2000-11-08 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000714

2000-11-08 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-11-08 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000714;LT PAYMENT 20000714;LV PAYMENT 20000714;MK PAYMENT 20000714;RO PAYMENT 20000714;SI PAYMENT 20000714