EP 1049789 A1 20001108 - AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT
Title (en)
AN AUTOREGULATORY SYSTEM FOR VALIDATING MICROBIAL GENES AS POSSIBLE ANTIMICROBIAL TARGETS USING A TETRACYCLINE-CONTROLLABLE ELEMENT
Title (de)
SELBSTREGULIERTES SYSTEM ZUM TESTEN VON MIKROBIELLEN GENEN, WELCHE EIN MÖGLICHES ZIEL VON ANTIMIKROBIELLEN STOFFEN SIND, UNTER VERWENDUNG VON EINEM DURCH TETRAZYKLIN-REGULIERTEM ELEMENT
Title (fr)
SYSTEME AUTOREGULATEUR DE VALIDATION DE GENES MICROBIENS EN TANT QU'EVENTUELLES CIBLES ANTIMICROBIENNES UTILISANT UN ELEMENT REGULABLE PAR LA TETRACYCLINE
Publication
Application
Priority
- US 9900371 W 19990112
- US 7164098 P 19980116
Abstract (en)
[origin: WO9936554A1] A screen has been designed to genetically engineer microbial pathogens so that expression of specific genes can be regulated in vitro and during host infection to facilitate the identification of bacterial genes essential for maintaining an infection. Specifically, gene regulatory elements which respond to the presence or absence of tetracycline are used to regulate the expression of endogenous bacterial genes. Because tetracycline is not normally present in animals, a tetracycline-regulated microbial gene can be controlled in vivo by adding or removing tetracycline from the infected animals' diet.
IPC 1-7
IPC 8 full level
C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/10 (2006.01); C12N 15/63 (2006.01); C12N 15/90 (2006.01); C12Q 1/04 (2006.01); C12Q 1/68 (2006.01); C12R 1/445 (2006.01)
CPC (source: EP)
C12N 15/1034 (2013.01); C12N 15/635 (2013.01); C12N 15/90 (2013.01)
Citation (search report)
See references of WO 9936554A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9936554 A1 19990722; AU 2312699 A 19990802; EP 1049789 A1 20001108; JP 2002508972 A 20020326
DOCDB simple family (application)
US 9900371 W 19990112; AU 2312699 A 19990112; EP 99903005 A 19990112; JP 2000540255 A 19990112