Global Patent Index - EP 1049805 A2

EP 1049805 A2 2000-11-08 - ASSAY FOR PREDICTING THE ANGIOGRAPHIC RESPONSE TO LIPID-LOWERING THERAPY IN PATIENTS

Title (en)

ASSAY FOR PREDICTING THE ANGIOGRAPHIC RESPONSE TO LIPID-LOWERING THERAPY IN PATIENTS

Title (de)

TESTVERFAHREN ZUR VORHERSAGE DER ANGIOGRAPHISCHEN ANTWORT AUF EINE LIPIDSENKENDE THERAPIE IN PATIENTEN

Title (fr)

DOSAGE PERMETTANT DE PREVOIR CHEZ DES PATIENTS LA REPONSE ANGIOGRAPHIQUE A UN TRAITEMENT HYPOLIPIDEMIANT

Publication

EP 1049805 A2 (EN)

Application

EP 99902536 A

Priority

  • EP 99902536 A
  • EP 9900150 W
  • EP 98200022 A

Abstract (en)

[origin: WO9935286A2] The present invention relates to an assay for testing the genetic predisposition to respond to lipid-lowering therapy in patients with coronary artery disease (CAD), comprising identifying the presence or absence of a TaqIB restriction site in intron 1 in both alleles of the cholesteryl ester transfer protein (CETP) gene by suitable molecular biological techniques; and correlating the presence of the restriction site on one or both alleles with a high or intermediate, susceptibility for lipid-lowering therapy. The invention further relates to a testkit for performing the assay and to a cholesterol ester transfer protein (CETP) gene marker for identifying individuals that may or may not be susceptible for lipid-lowering therapies.

IPC 1-7 (main, further and additional classification)

C12Q 1/68

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6883 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01)

Citation (search report)

See references of WO 9935286A3

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9935286 A2 19990715; WO 9935286 A3 19990916; AU 2279199 A 19990726; CA 2317940 A1 19990715; EP 0939136 A1 19990901; EP 1049805 A2 20001108; JP 2002504315 A 20020212

INPADOC legal status


2004-02-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030731

2000-11-08 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000713

2000-11-08 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE