EP 1049805 A2 20001108 - ASSAY FOR PREDICTING THE ANGIOGRAPHIC RESPONSE TO LIPID-LOWERING THERAPY IN PATIENTS
Title (en)
ASSAY FOR PREDICTING THE ANGIOGRAPHIC RESPONSE TO LIPID-LOWERING THERAPY IN PATIENTS
Title (de)
TESTVERFAHREN ZUR VORHERSAGE DER ANGIOGRAPHISCHEN ANTWORT AUF EINE LIPIDSENKENDE THERAPIE IN PATIENTEN
Title (fr)
DOSAGE PERMETTANT DE PREVOIR CHEZ DES PATIENTS LA REPONSE ANGIOGRAPHIQUE A UN TRAITEMENT HYPOLIPIDEMIANT
Publication
Application
Priority
- EP 99902536 A 19990106
- EP 9900150 W 19990106
- EP 98200022 A 19980107
Abstract (en)
[origin: WO9935286A2] The present invention relates to an assay for testing the genetic predisposition to respond to lipid-lowering therapy in patients with coronary artery disease (CAD), comprising identifying the presence or absence of a TaqIB restriction site in intron 1 in both alleles of the cholesteryl ester transfer protein (CETP) gene by suitable molecular biological techniques; and correlating the presence of the restriction site on one or both alleles with a high or intermediate, susceptibility for lipid-lowering therapy. The invention further relates to a testkit for performing the assay and to a cholesterol ester transfer protein (CETP) gene marker for identifying individuals that may or may not be susceptible for lipid-lowering therapies.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6883 (2018.01)
CPC (source: EP)
C12Q 1/6883 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01)
Citation (search report)
See references of WO 9935286A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9935286 A2 19990715; WO 9935286 A3 19990916; AU 2279199 A 19990726; CA 2317940 A1 19990715; EP 0939136 A1 19990901; EP 1049805 A2 20001108; JP 2002504315 A 20020212
DOCDB simple family (application)
EP 9900150 W 19990106; AU 2279199 A 19990106; CA 2317940 A 19990106; EP 98200022 A 19980107; EP 99902536 A 19990106; JP 2000527668 A 19990106