EP 1051188 A1 20001115 - MUCOSAL DELIVERY SYSTEM COMPRISING LIPOPHILIC THROMBIN INHIBITORS

Title (en)

MUCOSAL DELIVERY SYSTEM COMPRISING LIPOPHILIC THROMBIN INHIBITORS

Title (de)

MUKOSALE ABGABEFORMULIERUNGEN ENTHALTEND LIPOPHILIE THROMBININHIBITOREN

Title (fr)

SYSTEME D'ADMINISTRATION PAR LES MUQUEUSES COMPRENANT UN INHIBITEUR DE THROMBINE LIPOPHILE

Publication

EP 1051188 A1 20001115 (EN)

Application

EP 98958993 A 19981125

Priority

GB 9803511 W 19981125
GB 9724786 A 19971125

Abstract (en)

[origin: WO9926652A1] A composition for the delivery across a mucosal surface of a lipophilic thrombin inhibitor comprising a lipophilic thrombin inhibitor and a non-ionic surfactant. Preferably, the mucosal surface is in the gastrointestinal tract, nose, mouth, rectum or vagina. Advantageously, the thrombin inhibitor is a peptide boronic acid or ester derivative thereof. Conveniently, the non-ionic surfactant is an ethoxylated glyceride. Suitably, the composition is contained within a capsule. In addition, the invention also relates to methods of making said compositions and the use of said compositions in medicine.

IPC 1-7

A61K 38/55; A61K 31/69; A61K 47/14; A61K 47/06; A61K 47/34

IPC 8 full level

A61K 9/48 (2006.01); A61K 38/00 (2006.01); A61K 38/46 (2006.01); A61K 47/12 (2006.01); A61K 47/14 (2006.01); A61K 47/26 (2006.01); A61K 47/30 (2006.01); A61K 47/34 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61K 47/42 (2006.01); A61K 47/44 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 43/00 (2006.01)

CPC (source: EP)

A61K 9/4858 (2013.01); A61K 47/14 (2013.01); A61K 47/26 (2013.01); A61K 47/44 (2013.01); A61P 7/02 (2017.12); A61P 9/00 (2017.12); A61P 43/00 (2017.12)

Citation (search report)

See references of WO 9926652A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9926652 A1 19990603; AU 1493499 A 19990615; AU 739270 B2 20011011; CA 2310775 A1 19990603; EP 1051188 A1 20001115; GB 9724786 D0 19980121; JP 2001523728 A 20011127; NO 20002647 D0 20000524; NO 20002647 L 20000524

DOCDB simple family (application)

GB 9803511 W 19981125; AU 1493499 A 19981125; CA 2310775 A 19981125; EP 98958993 A 19981125; GB 9724786 A 19971125; JP 2000521854 A 19981125; NO 20002647 A 20000524