Global Patent Index - EP 1051398 A1

EP 1051398 A1 2000-11-15 - THERMODYNAMICALLY STABLE FORM OF (R)-3- (4-FLUOROPHENYL) SULPHONYL]AMINO] -1,2,3,4- TETRAHYDRO -9H-CARBAZOLE -9-PROPANOIC ACID (RAMATROBAN)

Title (en)

THERMODYNAMICALLY STABLE FORM OF (R)-3- (4-FLUOROPHENYL) SULPHONYL]AMINO] -1,2,3,4- TETRAHYDRO -9H-CARBAZOLE -9-PROPANOIC ACID (RAMATROBAN)

Title (de)

THERMODYNAMISCH STABILE FORM VON (R) -3- [[(4-FLUOROPHENYL) SULPHONYL] AMINO] - 1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID (RAMATROBAN)

Title (fr)

FORME THERMODYNAMIQUEMENT STABLE D'UN ACIDE (R)-3- (4-FLUOROPHENYL) SULFONYL]AMINO] -1,2,3,4-TETRAHYDRO -9H-CARBAZOLE -9-PROPIONIQUE (RAMATROBANE)

Publication

EP 1051398 A1 (EN)

Application

EP 98961506 A

Priority

  • DE 19757983 A
  • JP 9805844 W

Abstract (en)

[origin: DE19757983A1] The present invention relates to a thermodynamically stable modification of the active compound ramatroban of formula (I). The thermodynamically stable form is prepared either by melting of the metastable form and subsequent recrystallization or by seeding a solution of the metastable active compound with a seed crystal of the thermodynamically stable form. The thermodynamically stable active compound can be employed as an asthma agent.

IPC 1-7 (main, further and additional classification)

C07D 209/88

IPC 8 full level (invention and additional information)

A61K 31/403 (2006.01); A61P 7/00 (2006.01); C07D 209/88 (2006.01)

CPC (invention and additional information)

C07D 209/88 (2013.01)

Citation (search report)

See references of WO 9933803A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19757983 A1 19990701; AR 013803 A1 20010110; AT 263152 T 20040415; AU 1687499 A 19990719; AU 744242 B2 20020221; BG 104554 A 20010531; BG 65024 B1 20061229; BR 9814496 A 20001010; CA 2313230 A1 19990708; CN 1140510 C 20040303; CN 1282320 A 20010131; CO 4970800 A1 20001107; DK 1051398 T3 20040719; EP 1051398 A1 20001115; EP 1051398 B1 20040331; ES 2218874 T3 20041116; GT 199800198 A 19981215; HK 1034517 A1 20041231; HN 1998000186 A 19991103; HU 0004432 A2 20010628; HU 0004432 A3 20021028; ID 25446 A 20001005; IL 136278 A 20050320; IL 136278 D0 20010520; IN 192932 B 20040612; JP 2001527067 A 20011225; JP 2006151977 A 20060615; JP 3817668 B2 20060906; JP 4411269 B2 20100210; NO 20003217 A 20000621; NO 20003217 D0 20000621; NZ 504741 A 20021025; PE 01152000 A1 20000326; PL 341359 A1 20010409; PT 1051398 E 20040730; RU 2220137 C2 20031227; SK 285109 B6 20060601; SK 9752000 A3 20010212; TR 200001936 T2 20010122; TW 552258 B 20030911; UA 66832 C2 20001215; US 6362214 B1 20020326; UY 25324 A1 20001229; WO 9933803 A1 19990708; ZA 9811817 B 19990629

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