EP 1051398 A1 20001115 - THERMODYNAMICALLY STABLE FORM OF (R)-3- (4-FLUOROPHENYL) SULPHONYL]AMINO] -1,2,3,4- TETRAHYDRO -9H-CARBAZOLE -9-PROPANOIC ACID (RAMATROBAN)
Title (en)
THERMODYNAMICALLY STABLE FORM OF (R)-3- (4-FLUOROPHENYL) SULPHONYL]AMINO] -1,2,3,4- TETRAHYDRO -9H-CARBAZOLE -9-PROPANOIC ACID (RAMATROBAN)
Title (de)
THERMODYNAMISCH STABILE FORM VON (R) -3- [[(4-FLUOROPHENYL) SULPHONYL] AMINO] - 1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOIC ACID (RAMATROBAN)
Title (fr)
FORME THERMODYNAMIQUEMENT STABLE D'UN ACIDE (R)-3- (4-FLUOROPHENYL) SULFONYL]AMINO] -1,2,3,4-TETRAHYDRO -9H-CARBAZOLE -9-PROPIONIQUE (RAMATROBANE)
Publication
Application
Priority
- DE 19757983 A 19971224
- JP 9805844 W 19981224
Abstract (en)
[origin: US6362214B1] The present invention relates to a thermodynamically stable modification of the active compound ramatroban of formula (I). The thermodynamically stable form is prepared either by melting of the metastable form and subsequent recrystallization or by seeding a solution of the metastable active compound with a seed crystal of the thermodynamically stable form. The thermodynamically stable active compound can be employed as an asthma agent.
IPC 1-7
IPC 8 full level
A61K 31/403 (2006.01); A61P 7/00 (2006.01); C07D 209/88 (2006.01)
CPC (source: EP US)
A61P 7/00 (2018.01 - EP); A61P 7/02 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 37/08 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 209/88 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
US 6362214 B1 20020326; AR 013803 A1 20010110; AT E263152 T1 20040415; AU 1687499 A 19990719; AU 744242 B2 20020221; BG 104554 A 20010531; BG 65024 B1 20061229; BR 9814496 A 20001010; CA 2313230 A1 19990708; CN 1140510 C 20040303; CN 1282320 A 20010131; CO 4970800 A1 20001107; DE 19757983 A1 19990701; DE 69822882 D1 20040506; DE 69822882 T2 20050203; DK 1051398 T3 20040719; EP 1051398 A1 20001115; EP 1051398 B1 20040331; ES 2218874 T3 20041116; GT 199800198 A 19981215; HK 1034517 A1 20011026; HN 1998000186 A 19991103; HU P0004432 A2 20010628; HU P0004432 A3 20021028; ID 25446 A 20001005; IL 136278 A0 20010520; IL 136278 A 20050320; IN 192932 B 20040612; JP 2001527067 A 20011225; JP 2006151977 A 20060615; JP 3817668 B2 20060906; JP 4411269 B2 20100210; KR 100586350 B1 20060607; KR 20010033529 A 20010425; MY 116312 A 20031231; NO 20003217 D0 20000621; NO 20003217 L 20000621; NO 316618 B1 20040308; NZ 504741 A 20021025; PE 20000115 A1 20000326; PL 341359 A1 20010409; PT 1051398 E 20040730; RU 2220137 C2 20031227; SI 1051398 T1 20040831; SK 285109 B6 20060601; SK 9752000 A3 20010212; TR 200001936 T2 20010122; TW 552258 B 20030911; UA 66832 C2 20040615; UY 25324 A1 20001229; UY 25575 A1 19991117; WO 9933803 A1 19990708; ZA 9811817 B 19990629
DOCDB simple family (application)
US 58225000 A 20000622; AR P980106318 A 19981211; AT 98961506 T 19981224; AU 1687499 A 19981224; BG 10455400 A 20000623; BR 9814496 A 19981224; CA 2313230 A 19981224; CN 98812405 A 19981224; CO 98076459 A 19981223; DE 19757983 A 19971224; DE 69822882 T 19981224; DK 98961506 T 19981224; EP 98961506 A 19981224; ES 98961506 T 19981224; GT 199800198 A 19981215; HK 01105260 A 20010727; HN 1998000186 A 19981209; HU P0004432 A 19981224; ID 20001226 A 19981224; IL 13627898 A 19981224; IN 43MU2000 A 19981224; JP 2000526487 A 19981224; JP 2005340586 A 20051125; JP 9805844 W 19981224; KR 20007007031 A 20000623; MY PI19985837 A 19981222; NO 20003217 A 20000621; NZ 50474198 A 19981224; PE 00127298 A 19981222; PL 34135998 A 19981224; PT 98961506 T 19981224; RU 2000119741 A 19981224; SI 9830656 T 19981224; SK 9752000 A 19981224; TR 200001936 T 19981224; TW 87121479 A 19981223; UA 00074335 A 19981224; UY 25324 A 19981223; UY 25575 A 19990618; ZA 9811817 A 19981223