Global patent index - EP 1051503 A1

EP 1051503 A1 2000-11-15 - METHOD FOR PRODUCING, BY PLANT CELLS, $g(a) 1?-ANTITRYPSIN AND ITS ALLELES, AND PRODUCTS CONTAINING THE RESULTING $g(a) 1?-ANTITRYPSIN

Title (en)

METHOD FOR PRODUCING, BY PLANT CELLS, $g(a) 1?-ANTITRYPSIN AND ITS ALLELES, AND PRODUCTS CONTAINING THE RESULTING $g(a) 1?-ANTITRYPSIN

Title (de)

VERFAHREN ZUR PRODUKTION VON ALPHA1-ANTITRYPSIN DURCH PFLANZENZELLEN

Title (fr)

PROCEDE DE PRODUCTION, PAR DES CELLULES VEGETALES, D' ALPHA 1-ANTITRYPSINE ET DE SES VARIANTES, ET PRODUITS CONTENANT L' ALPHA1-ANTITRYPSINE AINSI OB

Publication

EP 1051503 A1 (FR)

Application

EP 99901670 A

Priority

  • FR 9900195 W
  • FR 9801089 A

Abstract (en)

[origin: FR2774379A1] he invention concerns a method for producing alpha 1-antitrypsin ( alpha 1-AT), or alleles thereof characterised in that it consists in: (i) introducing in the monocotyledon plant cells, a nucleic acid comprising a sequence coding for alpha 1-antitrypsin ( alpha 1-AT) or for an allele thereof, the alleles being differentiated from natural human alpha 1-AT by one or several substitution(s), deletion(s) or insertion(s) of amino acids, and optionally a sequence coding for a selective agent; (ii) selecting the cells having integrated the nucleic acid in stable manner; (iii) propagating the transformed cells in culture, or regeneration of entire chimerical or transgenic plants; (iv) recuperating and optionally purifying the resulting alpha 1-antitrypsin or its alleles.

IPC 1-7 (main, further and additional classification)

C12N 15/82; A01H 5/00; A01H 5/10; A61K 7/00; A61K 38/57; C07K 14/81; C07K 16/38; C12N 5/10; C12N 15/15

IPC 8 full level (invention and additional information)

C07K 14/81 (2006.01); C12N 15/15 (2006.01); C12N 15/29 (2006.01); C12N 15/82 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 15/8257 (2013.01); C07K 14/8125 (2013.01); A61K 38/00 (2013.01); C07K 2319/02 (2013.01)

Citation (search report)

See references of WO 9938987A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2774379 A1 19990806; FR 2774379 B1 20020329; AU 2169399 A 19990816; EP 1051503 A1 20001115; WO 9938987 A1 19990805; WO 9938987 A8 19990930

INPADOC legal status

2003-12-03 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20031009

2000-11-15 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000726

2000-11-15 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE