Global Patent Index - EP 1051508 A1

EP 1051508 A1 2000-11-15 - PANCREATIC EUKARYOTIC TRANSLATION INITIATION FACTOR-2ALPHA KINASE

Title (en)

PANCREATIC EUKARYOTIC TRANSLATION INITIATION FACTOR-2ALPHA KINASE

Title (de)

PANKREATISCHE EUKARYOTISCHE TRANSLATIONS-INITIIERUNGSFAKTOR-2-ALPHA-KINASE

Title (fr)

KINASE PANCREATIQUE EUCARYOTE PHOSPHORYLANT LE FACTEUR 2ALPHA D'INITIATION DE TRADUCTION EUCARYOTE ET PANCREATIQUE

Publication

EP 1051508 A1 (EN)

Application

EP 99902185 A

Priority

  • US 9900623 W
  • US 7303198 P
  • US 10999298 P

Abstract (en)

[origin: WO9938994A1] The invention includes pancreatic eukaryotic translation initiation factor-2 alpha kinase (PEK) and DNA sequences which encode them. Northern blot analysis shows that the gene is expressed in a wide variety tissues, with highest expression in pancreas. Human and rat PEK were expressed in Sf-9 insect cells and were shown to phosphorylate eukaryotic translation initiation factor-2 alpha . Recombinant vectors and host cells containing PEK genes are disclosed, as are methods for recombinant production, anti-PEK antibodies and assay methods.

IPC 1-7 (main, further and additional classification)

C12Q 1/00; C07H 21/04; C07K 16/00; C12N 1/20; C12N 5/00; C12N 9/12; C12N 15/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C07K 16/40 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12Q 1/48 (2006.01); G01N 33/573 (2006.01)

CPC (invention and additional information)

C12N 9/1205 (2013.01); C07K 16/40 (2013.01); C12Q 1/48 (2013.01); G01N 33/573 (2013.01); G01N 2333/91205 (2013.01)

Citation (search report)

See references of WO 9938994A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9938994 A1 19990805; AU 2222599 A 19990816; AU 751997 B2 20020905; CA 2319095 A1 19990805; EP 1051508 A1 20001115; HU 0101140 A2 20010730; IL 137331 D0 20010724; JP 2002503452 A 20020205

INPADOC legal status


2005-02-02 [18R] REFUSED

- Effective date: 20040804

2000-11-15 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000727

2000-11-15 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-11-15 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000727;LT PAYMENT 20000727;LV PAYMENT 20000727;RO PAYMENT 20000727;SI PAYMENT 20000727