Global Patent Index - EP 1052521 A1

EP 1052521 A1 2000-11-15 - Compensation of radiation damping during selective pulses in NMR spectroscopy

Title (en)

Compensation of radiation damping during selective pulses in NMR spectroscopy

Title (de)

Kompensation von Strahlungsdämpfung während selektiver Pulse in der Kernspinresonanzspektroskopie

Title (fr)

Compensation de l'amortissement de radiation pendant des impulsions sélectives dans la spectroscopie à RMN

Publication

EP 1052521 A1 (EN)

Application

EP 99108737 A

Priority

EP 99108737 A

Abstract (en)

A method for compensating radiation damping (=RD) effects during selective or non-selective radio frequency (=rf) pulses in nuclear magnetic resonance (=NMR) spectroscopy comprises the following steps: 1) Choose an rf pulse suitably shaped for a selective or non-selective excitation, inversion or refocussing experiment and calculate the expected transverse magnetisation <MATH> where i = <SQRT>-1</SQRT> by solving the Bloch equations on-resonance, assuming that there is no RD; 2) Calibrate the rf amplitude on-resonance on a sample with little RD; 3) Estimate the RD rate <MATH> for a sample with RD, where gamma is the gyromagnetic ratio, eta is the filling factor, Q is the quality factor and M0 is the equilibrium magnetisation; 4) Define a compensated rf pulse shape using the estimate of step 3), given by <MATH> where i = <SQRT>-1</SQRT> , omega +<unc)<t) is the ordinary uncompensated shape of the selective or non-selective rf pulse and M+(t) is the time dependent transverse magnetisation; 5) Record the on-resonance response for the said selective or non-selective excitation, inversion or refocussing experiment. This method has general applicability for any amplitude or frequency modulated rf pulse and presents a general way to compensate for radiation damping during the application of selective rf pulses. <IMAGE>

IPC 1-7 (main, further and additional classification)

G01R 33/46

IPC 8 full level (invention and additional information)

G01R 33/48 (2006.01)

CPC (invention and additional information)

G01R 33/446 (2013.01)

Citation (search report)

[AD] W.S.WARREN ET AL.: "Dynamics of radiation damping in nuclear magnetic resonance", J.CHEM.PHYS., vol. 91, no. 10, 1989, pages 5895 - 5904, XP002116030

Designated contracting state (EPC)

CH DE FR GB LI

EPO simple patent family

EP 1052521 A1 20001115; EP 1052521 B1 20041020; DE 69921298 D1 20041125; DE 69921298 T2 20051027

INPADOC legal status


2016-12-30 [REG CH PL] PATENT CEASED

- Ref Legal Event Code: PL

2016-07-29 [PGFP DE] POSTGRANT: ANNUAL FEES PAID TO NATIONAL OFFICE

- Ref Country Code: DE

- Ref Legal Event Code: PGFP

- Payment date: 20160512

- Year of fee payment: 18

2015-08-31 [PGFP FR] POSTGRANT: ANNUAL FEES PAID TO NATIONAL OFFICE

- Ref Country Code: FR

- Ref Legal Event Code: PGFP

- Payment date: 20150519

- Year of fee payment: 17

2015-07-31 [PGFP GB] POSTGRANT: ANNUAL FEES PAID TO NATIONAL OFFICE

- Ref Country Code: GB

- Ref Legal Event Code: PGFP

- Payment date: 20150521

- Year of fee payment: 17

2015-07-31 [PGFP CH] POSTGRANT: ANNUAL FEES PAID TO NATIONAL OFFICE

- Ref Country Code: CH

- Ref Legal Event Code: PGFP

- Payment date: 20150520

- Year of fee payment: 17

2005-10-12 [26N] NO OPPOSITION FILED

- Ref Legal Event Code: 26N

- Effective date: 20050721

2005-09-30 [ET] FR: TRANSLATION FILED

- Ref Legal Event Code: ET

2005-05-31 [REG CH NV] NEW AGENT

- Ref Legal Event Code: NV

- Representative's name: RIEDERER HASLER & PARTNER PATENTANWAELTE AG

2004-11-25 [REF] CORRESPONDS TO:

- Ref Legal Event Code: REF

- Ref Document Number: 69921298

- Country of Ref Document: DE

- Date of Ref Document: 2004-11-25

- Kind Code of Ref Document: P

2004-10-29 [REG CH EP] ENTRY IN THE NATIONAL PHASE

- Ref Legal Event Code: EP

2004-10-20 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): CH DE FR GB LI

2004-10-20 [REG GB FG4D] EUROPEAN PATENT GRANTED

- Ref Legal Event Code: FG4D

2002-05-29 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: BRUKER BIOSPIN AG

- Ref Legal Event Code: RAP1

2001-08-01 [AKX] PAYMENT OF DESIGNATION FEES

- Ref Legal Event Code: AKX

- Free Format Text: CH DE FR GB LI

2001-02-21 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: CHEN, JIN HONG, DR.

2001-02-21 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: JERSCHOW, ALEXEJ, DR.

2001-02-21 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: BODENHAUSEN, GEOFFREY, PROF.

2001-01-03 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: CHEN, JIN HONG, DR.

2001-01-03 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: JERSCHOW, ALEXEJ, DR.

2001-01-03 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: RODENHAUSEN, GEOFFREY, PROF.

2000-11-15 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991111

2000-11-15 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): CH DE FR GB LI

2000-11-15 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL;LT;LV;MK;RO;SI