EP 1052998 A1 20001122 - COMPOSITIONS AND METHODS FOR MODULATING CYTOKINE RELEASE IN RESPONSE TO GENOTOXIC AGENTS
Title (en)
COMPOSITIONS AND METHODS FOR MODULATING CYTOKINE RELEASE IN RESPONSE TO GENOTOXIC AGENTS
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULIERUNG VON CYTOKIN FREISETZUNG ERZEUGT DURCH GENOTOXISCHE MITTELN
Title (fr)
COMPOSITIONS ET METHODES DE MODULATION DE LIBERATION DE CYTOKINE EN REPONSE A DES AGENTS GENOTOXIQUES
Publication
Application
Priority
- US 9902348 W 19990204
- US 7364098 P 19980204
Abstract (en)
[origin: WO9939720A1] A previously unknown mechanism for cytokine release in response to genotoxic agents, as well as therapeutic and diagnostic procedures and techniques which are based on that mechanism, are disclosed. The mechanism involves the recognition of damaged DNA by DNA-protein kinases and the subsequent phosphorylation of substrates that leads to cytokine release. Methods to modulate the activity of DNA-protein kinases and thus the release of cytokines in response to genotoxic agents are described. Assays for DNA-protein kinase activity which can be used to monitor such modulation are also disclosed.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/436 (2006.01); A61K 38/13 (2006.01); A61K 41/00 (2006.01); A61K 45/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/436 (2013.01); A61K 38/13 (2013.01); A61K 41/00 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9939720 A1 19990812; AU 2494499 A 19990823; CA 2319567 A1 19990812; CN 1296413 A 20010523; EP 1052998 A1 20001122; EP 1052998 A4 20030226; IL 137253 A0 20010724; JP 2002502820 A 20020129
DOCDB simple family (application)
US 9902348 W 19990204; AU 2494499 A 19990204; CA 2319567 A 19990204; CN 99804851 A 19990204; EP 99904568 A 19990204; IL 13725399 A 19990204; JP 2000530217 A 19990204