EP 1052998 A4 20030226 - COMPOSITIONS AND METHODS FOR MODULATING CYTOKINE RELEASE IN RESPONSE TO GENOTOXIC AGENTS
Title (en)
COMPOSITIONS AND METHODS FOR MODULATING CYTOKINE RELEASE IN RESPONSE TO GENOTOXIC AGENTS
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULIERUNG VON CYTOKIN FREISETZUNG ERZEUGT DURCH GENOTOXISCHE MITTELN
Title (fr)
COMPOSITIONS ET METHODES DE MODULATION DE LIBERATION DE CYTOKINE EN REPONSE A DES AGENTS GENOTOXIQUES
Publication
Application
Priority
- US 9902348 W 19990204
- US 7364098 P 19980204
Abstract (en)
[origin: WO9939720A1] A previously unknown mechanism for cytokine release in response to genotoxic agents, as well as therapeutic and diagnostic procedures and techniques which are based on that mechanism, are disclosed. The mechanism involves the recognition of damaged DNA by DNA-protein kinases and the subsequent phosphorylation of substrates that leads to cytokine release. Methods to modulate the activity of DNA-protein kinases and thus the release of cytokines in response to genotoxic agents are described. Assays for DNA-protein kinase activity which can be used to monitor such modulation are also disclosed.
IPC 1-7
A61K 31/436; A61K 31/70; A61K 7/40; A61K 7/42; A61K 38/43; A61P 35/00; A61K 31/435
IPC 8 full level
A61K 45/00 (2006.01); A61K 31/00 (2006.01); A61K 31/436 (2006.01); A61K 38/13 (2006.01); A61K 41/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/436 (2013.01); A61K 38/13 (2013.01); A61K 41/00 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12)
Citation (search report)
- [X] EP 0525960 A1 19930203 - AMERICAN HOME PROD [US]
- [X] ROSENZWEIG K E ET AL: "Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.", CLINICAL CANCER RESEARCH: AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. UNITED STATES JUL 1997, vol. 3, no. 7, July 1997 (1997-07-01), pages 1149 - 1156, XP001069065, ISSN: 1078-0432
- [X] MOLNAR-KIMBER K L ET AL: "Comparison of effects of sirolimus on cytokine dependent and cytokine independent proliferation.", INFLAMMATION RESEARCH: OFFICIAL JOURNAL OF THE EUROPEAN HISTAMINE RESEARCH SOCIETY... [ET AL.]. SWITZERLAND AUG 1995, vol. 44 Suppl 2, August 1995 (1995-08-01), pages S189 - S190, XP001070575, ISSN: 1023-3830
- [PX] HOSOI Y ET AL: "A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation.", INTERNATIONAL JOURNAL OF CANCER. JOURNAL INTERNATIONAL DU CANCER. UNITED STATES 23 NOV 1998, vol. 78, no. 5, 23 November 1998 (1998-11-23), pages 642 - 647, XP002919460, ISSN: 0020-7136
- [PX] BASU S ET AL: "The DNA-dependent protein kinase participates in the activation of NF kappa B following DNA damage.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 9 JUN 1998, vol. 247, no. 1, 9 June 1998 (1998-06-09), pages 79 - 83, XP001097650, ISSN: 0006-291X
- See references of WO 9939720A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9939720 A1 19990812; AU 2494499 A 19990823; CA 2319567 A1 19990812; CN 1296413 A 20010523; EP 1052998 A1 20001122; EP 1052998 A4 20030226; IL 137253 A0 20010724; JP 2002502820 A 20020129
DOCDB simple family (application)
US 9902348 W 19990204; AU 2494499 A 19990204; CA 2319567 A 19990204; CN 99804851 A 19990204; EP 99904568 A 19990204; IL 13725399 A 19990204; JP 2000530217 A 19990204