EP 1053002 A1 20001122 - TREATMENT OF BONY DEFECTS WITH OSTEOBLAST PRECURSOR CELLS
Title (en)
TREATMENT OF BONY DEFECTS WITH OSTEOBLAST PRECURSOR CELLS
Title (de)
BEHANDLUNG VON KNOCHENDEFEKTEN OSTEOBLAST-VORLÄUFERZELLEN
Title (fr)
TRAITEMENT DE MALFORMATIONS OSSEUSES AVEC DES CELLULES PRECURSEURS OSTEOBLASTIQUES
Publication
Application
Priority
- US 9902946 W 19990210
- US 7424098 P 19980210
- US 7445198 P 19980212
Abstract (en)
[origin: WO9939724A1] Healing of bony defects is promoted by suspending osteoblast precursor cells (OPCs) in a porous matrix, which is implanted in the bony defects. The OPCs may be transformed to express a bone morphogenetic protein (BMP), such as BMP-2. Devices are also disclosed for introducing the OPCs into bony defects. One device is a cannula (100) having concentric passageways, such that an endoscope (122) can be introduced through one of the passageways, while the OPCs are introduced through the endoscope or through another passageway without increasing pressure on the OPCs to such an extent that the cells are damaged. A cartridge unit (126) can be inserted through an endoscope to gently advance a cellular suspension through a catheter into the bone.
IPC 1-7
A61K 38/00; A61K 38/19; A61K 48/00; A61B 17/56; C07K 14/51; A61F 2/28
IPC 8 full level
A61B 17/56 (2006.01); A61B 17/88 (2006.01); A61F 2/28 (2006.01); A61F 2/46 (2006.01); A61K 9/00 (2006.01); A61K 35/12 (2006.01); A61K 38/18 (2006.01); A61K 38/22 (2006.01); A61K 48/00 (2006.01); A61L 27/00 (2006.01); A61L 27/26 (2006.01); A61L 27/38 (2006.01); A61L 27/44 (2006.01); A61L 29/00 (2006.01); A61P 19/00 (2006.01); A61P 19/10 (2006.01); C07K 14/51 (2006.01); C12N 5/06 (2006.01); C12N 5/077 (2010.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); A61B 1/00 (2006.01); A61F 2/00 (2006.01); A61F 2/02 (2006.01); A61F 2/44 (2006.01)
CPC (source: EP)
A61F 2/4601 (2013.01); A61K 38/1875 (2013.01); A61K 48/00 (2013.01); A61L 27/26 (2013.01); A61L 27/3821 (2013.01); A61L 27/3847 (2013.01); A61L 27/44 (2013.01); A61P 19/00 (2017.12); A61P 19/10 (2017.12); C12N 5/0654 (2013.01); A61B 1/00082 (2013.01); A61B 1/00154 (2013.01); A61B 1/0051 (2013.01); A61F 2/2803 (2013.01); A61F 2/44 (2013.01); A61F 2002/2817 (2013.01); A61F 2002/2839 (2013.01); A61F 2002/30062 (2013.01); A61F 2002/3028 (2013.01); A61F 2002/30298 (2013.01); A61F 2002/307 (2013.01); A61F 2002/4635 (2013.01); A61F 2210/0004 (2013.01); A61F 2230/0063 (2013.01); A61F 2230/0091 (2013.01); A61F 2250/0081 (2013.01); A61L 2430/02 (2013.01)
Citation (search report)
See references of WO 9939724A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9939724 A1 19990812; WO 9939724 A9 19991014; AU 2671599 A 19990823; CA 2320136 A1 19990812; EP 1053002 A1 20001122; JP 2002502822 A 20020129
DOCDB simple family (application)
US 9902946 W 19990210; AU 2671599 A 19990210; CA 2320136 A 19990210; EP 99906914 A 19990210; JP 2000530221 A 19990210