EP 1053007 A2 20001122 - METHODS AND COMPOSITIONS FOR MODULATING LEPTIN ACTIVITY
Title (en)
METHODS AND COMPOSITIONS FOR MODULATING LEPTIN ACTIVITY
Title (de)
METHODEN UND ZUSAMMENSETZUNGEN ZUR MODULIERUNG DER LEPTINAKTIVITÄT
Title (fr)
METHODES ET COMPOSITIONS POUR MODULER L'ACTIVITE DE LA LEPTINE
Publication
Application
Priority
- US 9902865 W 19990210
- US 7432098 P 19980211
- US 4427898 A 19980319
Abstract (en)
[origin: WO9940946A2] Administration of leptin affects food intake and body weight in animals and humans by a mechanism involving actions on specific regions of the hypothalamus. CIS-1, SOCS-1, SOCS-2 and SOCS-3 genes were investigated for their ability to antagonize leptin action. In mammalian cell lines, SOCS-3 completely blocked leptin induced signal-transduction, whereas CIS, SOCS-1 and SOC-2 were without effect. SOCS-3 is a major target of leptin action in leptin responsive cells in the hypothalamus, and SOCS-3 is a potent inhibitor of leptin signaling. Increased SOCS-3 activity in leptin-responsive neurons is a potential mechanism for the leptin resistance observed in syndromes of obesity, affective mood disorders and reproductive disorders.
IPC 1-7
A61K 38/17; A61K 31/70; A61K 31/00; A61K 39/395; A61K 48/00; C12N 5/10; G01N 33/50
IPC 8 full level
A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 3/04 (2006.01); A61P 15/00 (2006.01); A61P 25/24 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61P 3/04 (2017.12); A61P 15/00 (2017.12); A61P 25/24 (2017.12); A61P 43/00 (2017.12); C07K 14/4703 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
See references of WO 9940946A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9940946 A2 19990819; WO 9940946 A3 19991028; AU 2668699 A 19990830; CA 2320226 A1 19990819; EP 1053007 A2 20001122; JP 2002506004 A 20020226
DOCDB simple family (application)
US 9902865 W 19990210; AU 2668699 A 19990210; CA 2320226 A 19990210; EP 99906877 A 19990210; JP 2000531197 A 19990210