Global patent index - EP 1053235 A1

EP 1053235 A1 2000-11-22 - OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS

Title (en)

OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS

Title (de)

OXAZOLE DERIVATE ALS SEROTONIN-1A REZEPTOR AGONISTEN

Title (fr)

DERIVES D'OXAZOL UTILISES COMME AGONISTES DU RECEPTEUR 1A DE LA SEROTONINE

Publication

EP 1053235 A1 (EN)

Application

EP 99905632 A

Priority

  • US 9902210 W
  • US 1751798 A

Abstract (en)

[origin: WO9938864A1] This invention provides compounds of Formula (1), wherein R1 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, benzyloxy, trifluoromethyl, chloro, bromo, or fluoro; a dashed line indicates an optional bond; X is NR4, or no atom; R2 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkylalkyl wherein the cycloalkyl moiety is 3-8 cabon atoms and the alkyl moiety is 1-6 carbon atoms, aryl of 5-12 carbon atoms, or arylalkyl of 6-12 carbon atoms; R3 is aryl of 5-12 carbon atoms, arylalkyl of 6-12 carbon atoms, or heteroaryl of 5-12 ring atoms; R4 is hydrogen or alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of psychosis (e.g. schizophrenia), anxiety, depression and related CNS disorders and other conditions such as the treatment of alcohol and drug withdrawal, sexual dysfunction and memory deficits associated with Alzheimer's disease and other dementias.

IPC 1-7 (main, further and additional classification)

C07D 413/06; A61K 31/42; C07D 471/04

IPC 8 full level (invention and additional information)

A61K 31/437 (2006.01); A61K 31/454 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); A61P 43/00 (2006.01); C07D 413/06 (2006.01); C07D 471/04 (2006.01)

CPC (invention and additional information)

C07D 413/06 (2013.01); C07D 471/04 (2013.01)

Citation (search report)

See references of WO 9938864A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9938864 A1 19990805; AU 2575399 A 19990816; CA 2317515 A1 19990805; CN 1289333 A 20010328; EP 1053235 A1 20001122; JP 2002501920 A 20020122

INPADOC legal status

2003-10-22 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030415

2002-06-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WYETH

- Ref Legal Event Code: RAP1

2000-11-22 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000725

2000-11-22 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-11-22 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000725;LT PAYMENT 20000725;LV PAYMENT 20000725;RO PAYMENT 20000725;SI PAYMENT 20000725