EP 1053235 A1 20001122 - OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS
Title (en)
OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS
Title (de)
OXAZOLE DERIVATE ALS SEROTONIN-1A REZEPTOR AGONISTEN
Title (fr)
DERIVES D'OXAZOL UTILISES COMME AGONISTES DU RECEPTEUR 1A DE LA SEROTONINE
Publication
Application
Priority
- US 9902210 W 19990202
- US 1751798 A 19980203
Abstract (en)
[origin: WO9938864A1] This invention provides compounds of Formula (1), wherein R1 is hydrogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, benzyloxy, trifluoromethyl, chloro, bromo, or fluoro; a dashed line indicates an optional bond; X is NR4, or no atom; R2 is alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, cycloalkylalkyl wherein the cycloalkyl moiety is 3-8 cabon atoms and the alkyl moiety is 1-6 carbon atoms, aryl of 5-12 carbon atoms, or arylalkyl of 6-12 carbon atoms; R3 is aryl of 5-12 carbon atoms, arylalkyl of 6-12 carbon atoms, or heteroaryl of 5-12 ring atoms; R4 is hydrogen or alkyl of 1-6 carbon atoms; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of psychosis (e.g. schizophrenia), anxiety, depression and related CNS disorders and other conditions such as the treatment of alcohol and drug withdrawal, sexual dysfunction and memory deficits associated with Alzheimer's disease and other dementias.
IPC 1-7
IPC 8 full level
A61K 31/437 (2006.01); A61K 31/454 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 25/32 (2006.01); A61P 43/00 (2006.01); C07D 413/06 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP)
A61P 25/20 (2017.12); A61P 25/22 (2017.12); A61P 25/28 (2017.12); A61P 25/30 (2017.12); A61P 25/32 (2017.12); A61P 43/00 (2017.12); C07D 413/06 (2013.01); C07D 471/04 (2013.01)
Citation (search report)
See references of WO 9938864A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9938864 A1 19990805; AU 2575399 A 19990816; CA 2317515 A1 19990805; CN 1289333 A 20010328; EP 1053235 A1 20001122; JP 2002501920 A 20020122
DOCDB simple family (application)
US 9902210 W 19990202; AU 2575399 A 19990202; CA 2317515 A 19990202; CN 99802651 A 19990202; EP 99905632 A 19990202; JP 2000529332 A 19990202