Global Patent Index - EP 1053341 A1

EP 1053341 A1 2000-11-22 - USE OF NEGATIVE REGULATION ELEMENTS FOR NERVE-SPECIFIC EXPRESSION OF TRANSGENES

Title (en)

USE OF NEGATIVE REGULATION ELEMENTS FOR NERVE-SPECIFIC EXPRESSION OF TRANSGENES

Title (de)

ANWENDUNG NEGATIVREGULATIONSELEMENTER FÜR TRANSGEN SPEZIFISCHEN EXPRESSION

Title (fr)

UTILISATION D'ELEMENTS DE REGULATION NEGATIVE POUR L'EXPRESSION NEUROSPECIFIQUE DE TRANSGENES

Publication

EP 1053341 A1 (FR)

Application

EP 99900923 A

Priority

  • FR 9900061 W
  • FR 9801715 A

Abstract (en)

[origin: FR2774698A1] New recombinant nucleic acid (I) comprises a promoter; one or more NRSE (neuron restrictive silencer element) sequences and a therapeutic gene (II), arranged such that (II) is controlled by the promoter and this, in turn, is controlled by the NRSE sequences. Independent claims are also included for the following: (a) vectors containing (I); (b) defective recombinant virus (A) containing a gene under control of a promoter and NRSE sequences; (c) cells containing (I), the vector or virus; (d) composition containing (I), the vector or virus; (e) chimeric promoter consisting of a ubiquitous promoter and one or more NRSE sequences. - ACTIVITY : Antineurodegenerative; anticancer; antioxidant. - MECHANISM OF ACTION : Selective suppression of gene expression in non-neuronal cells. -

[origin: FR2774698A1] The invention concerns novel methods and constructs for controlling nucleic acid expression, in particular methods and constructs using NRSE sequences for obtaining a targeted expression of transgenes in the nerve cells in vivo or ex vivo. The invention is particularly adapted for in vivo gene transfer applications, for instance for therapeutic or scientific approach.

IPC 1-7 (main, further and additional classification)

C12N 15/86; A61K 48/00; C12N 5/06; C12N 5/10

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 31/711 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 25/28 (2006.01); C12N 5/06 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/12 (2006.01); C12N 15/86 (2006.01); C12P 21/02 (2006.01); C12R 1/93 (2006.01)

CPC (invention and additional information)

A61K 48/00 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); C12N 2710/10043 (2013.01); C12N 2799/022 (2013.01); C12N 2830/005 (2013.01); C12N 2830/008 (2013.01); C12N 2830/15 (2013.01); C12N 2830/32 (2013.01)

Citation (search report)

See references of WO 9941396A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2774698 A1 19990813; FR 2774698 B1 20020301; AU 2058199 A 19990830; AU 766153 B2 20031009; BR 9907759 A 20001017; CA 2321220 A1 19990819; CN 1221665 C 20051005; CN 1290303 A 20010404; CZ 20002906 A3 20001115; CZ 299915 B6 20081229; EP 1053341 A1 20001122; EP 1120466 A2 20010801; EP 1120466 A3 20030122; HU 0100660 A2 20010628; HU 0100660 A3 20031028; IL 137609 D0 20010724; JP 2002503476 A 20020205; KR 20070013362 A 20070130; NO 20004025 A 20001010; NO 20004025 D0 20000810; PL 198201 B1 20080630; PL 342265 A1 20010604; US 2006121013 A1 20060608; WO 9941396 A1 19990819; ZA 9901070 B 19990811

INPADOC legal status


2005-06-08 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041209

2004-09-15 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040729

2000-11-22 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000801

2000-11-22 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-11-22 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: SI PAYMENT 20000801