Global Patent Index - EP 1053356 A2

EP 1053356 A2 2000-11-22 - METHOD FOR DIAGNOSIS AND TREATMENT OF DISORDERS OF CARBOHYDRATE METABOLISM

Title (en)

METHOD FOR DIAGNOSIS AND TREATMENT OF DISORDERS OF CARBOHYDRATE METABOLISM

Title (de)

VERFAHREN ZUR DIAGNOSE UND BEHANDLUNG VON STÖRUNGEN DES CARBOHYDRATMETABOLISMUS

Title (fr)

DIAGNOSTIC ET TRAITEMENT DES TROUBLES DU METABOLISME GLUCIDIQUE

Publication

EP 1053356 A2 (EN)

Application

EP 99906659 A

Priority

  • SE 9900177 W
  • US 7442798 P

Abstract (en)

[origin: WO9941411A2] The present invention relates to a method of detecting a disorder in carbohydrate metabolism, such as type II diabetes (NIDDM), by detecting a promoter of an adenylate cyclase III gene, the promoter having enhanced activity. The present invention also relates to a promoter from an adenylate cyclase III gene having enhanced activity, and isolated DNA molecules containing this promoter. The promoter having enhanced activity can be part of a transgenic animal. In another embodiment, the invention relates to a method of treating a patient having a disorder in carbohydrate metabolism, such as type II diabetes (NIDDM), and a method of enhancing or restoring a patient's response to insulin. Each of these methods includes administering to the patient a down regulator, an antagonist, or an inhibitor of expression of the adenylate cyclase III gene, or of the activity of one of its gene products.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; A01K 67/027; C12N 9/88

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61K 45/00 (2006.01); A61P 3/08 (2006.01); A61P 5/50 (2006.01); A61P 43/00 (2006.01); C12N 5/10 (2006.01); C12N 9/88 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6883 (2013.01); C12N 9/88 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2267/0306 (2013.01); A01K 2267/0362 (2013.01); A01K 2267/0393 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01)

Citation (search report)

See references of WO 9941411A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9941411 A2 19990819; WO 9941411 A3 19990930; AU 2651299 A 19990830; CA 2319065 A1 19990819; EP 1053356 A2 20001122; JP 2002503483 A 20020205

INPADOC legal status


2002-05-29 [18W] WITHDRAWN

- Date of withdrawal: 20020404

2000-11-22 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000821

2000-11-22 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE