EP 1053356 A2 20001122 - METHOD FOR DIAGNOSIS AND TREATMENT OF DISORDERS OF CARBOHYDRATE METABOLISM
Title (en)
METHOD FOR DIAGNOSIS AND TREATMENT OF DISORDERS OF CARBOHYDRATE METABOLISM
Title (de)
VERFAHREN ZUR DIAGNOSE UND BEHANDLUNG VON STÖRUNGEN DES CARBOHYDRATMETABOLISMUS
Title (fr)
DIAGNOSTIC ET TRAITEMENT DES TROUBLES DU METABOLISME GLUCIDIQUE
Publication
Application
Priority
- SE 9900177 W 19990211
- US 7442798 P 19980211
Abstract (en)
[origin: WO9941411A2] The present invention relates to a method of detecting a disorder in carbohydrate metabolism, such as type II diabetes (NIDDM), by detecting a promoter of an adenylate cyclase III gene, the promoter having enhanced activity. The present invention also relates to a promoter from an adenylate cyclase III gene having enhanced activity, and isolated DNA molecules containing this promoter. The promoter having enhanced activity can be part of a transgenic animal. In another embodiment, the invention relates to a method of treating a patient having a disorder in carbohydrate metabolism, such as type II diabetes (NIDDM), and a method of enhancing or restoring a patient's response to insulin. Each of these methods includes administering to the patient a down regulator, an antagonist, or an inhibitor of expression of the adenylate cyclase III gene, or of the activity of one of its gene products.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 45/00 (2006.01); A61P 3/08 (2006.01); A61P 5/50 (2006.01); A61P 43/00 (2006.01); C12N 5/10 (2006.01); C12N 9/88 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6883 (2018.01)
CPC (source: EP)
A61P 3/08 (2017.12); A61P 5/50 (2017.12); A61P 43/00 (2017.12); C12N 9/88 (2013.01); C12N 15/8509 (2013.01); C12Q 1/6883 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2267/0306 (2013.01); A01K 2267/0362 (2013.01); A01K 2267/0393 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01)
Citation (search report)
See references of WO 9941411A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9941411 A2 19990819; WO 9941411 A3 19990930; AU 2651299 A 19990830; CA 2319065 A1 19990819; EP 1053356 A2 20001122; JP 2002503483 A 20020205
DOCDB simple family (application)
SE 9900177 W 19990211; AU 2651299 A 19990211; CA 2319065 A 19990211; EP 99906659 A 19990211; JP 2000531591 A 19990211