EP 1054690 A2 20001129 - HAPTEN-MODIFIED TUMOR CELL MEMBRANES AND THEIR USE
Title (en)
HAPTEN-MODIFIED TUMOR CELL MEMBRANES AND THEIR USE
Title (de)
HAPTEN MODIFIZIERTE TUMORZELLMEMBRANEN UND DEREN VERWENDUNG
Title (fr)
MEMBRANES DE CELLULES TUMORALES MODIFIEES PAR DES HAPTENES ET PROCEDES DE FABRICATION ET D'UTILISATION DE MEMBRANES DE CELLULES TUMORALES MODIFIEES
Publication
Application
Priority
- US 9903536 W 19990217
- US 2501298 A 19980217
Abstract (en)
[origin: WO9940925A2] The present invention is directed to isolated tumor cell membranes, compositions thereof, methods of making the membranes and compositions, and methods of treating cancer. The compositions of the present invention include a composition prepared from a tumor cell which is hapten modified. The tumor cell membranes and compositions of the invention have the properties, when administered to a mammal suffering from a malignant tumor of the same type as said tumor cell, of eliciting T lymphocytes that infiltrate the tumor of the mammal, of eliciting an inflammatory immune response against the tumor of the mammal, and of eliciting a delayed-type hypersensitivity response to the tumor of the mammal. The membranes and compositions of the invention also stimulate T cells in vitro. The methods of the present invention are directed to treating cancer comprising administering a therapeutically effective amount of a tumor cell membrane. The present invention is also directed to a method of making a hapten-modified tumor cell membrane and dosage forms containing the membranes.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)
CPC (source: EP KR US)
A61K 39/001102 (2018.08 - EP KR US); A61K 39/385 (2013.01 - KR); A61P 35/00 (2018.01 - EP); A61P 43/00 (2018.01 - EP); A61K 2039/6012 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9940925 A2 19990819; WO 9940925 A3 19991021; AR 015237 A1 20010418; AU 2686999 A 19990830; BR 9907912 A 20001024; CA 2320969 A1 19990819; CN 1291105 A 20010411; EP 1054690 A2 20001129; IL 137791 A0 20011031; JP 2002502880 A 20020129; KR 20010041018 A 20010515; PL 342856 A1 20010716; ZA 991245 B 19990818
DOCDB simple family (application)
US 9903536 W 19990217; AR P990100710 A 19990223; AU 2686999 A 19990217; BR 9907912 A 19990217; CA 2320969 A 19990217; CN 99803065 A 19990217; EP 99907137 A 19990217; IL 13779199 A 19990217; JP 2000531176 A 19990217; KR 20007009049 A 20000817; PL 34285699 A 19990217; ZA 991245 A 19990217