Global Patent Index - EP 1054690 A2

EP 1054690 A2 2000-11-29 - HAPTEN-MODIFIED TUMOR CELL MEMBRANES AND THEIR USE

Title (en)

HAPTEN-MODIFIED TUMOR CELL MEMBRANES AND THEIR USE

Title (de)

HAPTEN MODIFIZIERTE TUMORZELLMEMBRANEN UND DEREN VERWENDUNG

Title (fr)

MEMBRANES DE CELLULES TUMORALES MODIFIEES PAR DES HAPTENES ET PROCEDES DE FABRICATION ET D'UTILISATION DE MEMBRANES DE CELLULES TUMORALES MODIFIEES

Publication

EP 1054690 A2 (EN)

Application

EP 99907137 A

Priority

  • US 9903536 W
  • US 2501298 A

Abstract (en)

[origin: WO9940925A2] The present invention is directed to isolated tumor cell membranes, compositions thereof, methods of making the membranes and compositions, and methods of treating cancer. The compositions of the present invention include a composition prepared from a tumor cell which is hapten modified. The tumor cell membranes and compositions of the invention have the properties, when administered to a mammal suffering from a malignant tumor of the same type as said tumor cell, of eliciting T lymphocytes that infiltrate the tumor of the mammal, of eliciting an inflammatory immune response against the tumor of the mammal, and of eliciting a delayed-type hypersensitivity response to the tumor of the mammal. The membranes and compositions of the invention also stimulate T cells in vitro. The methods of the present invention are directed to treating cancer comprising administering a therapeutically effective amount of a tumor cell membrane. The present invention is also directed to a method of making a hapten-modified tumor cell membrane and dosage forms containing the membranes.

IPC 1-7 (main, further and additional classification)

A61K 39/00; A61K 39/385

IPC 8 full level (invention and additional information)

A61K 39/00 (2006.01); A61K 39/385 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 39/0011 (2013.01); A61K 2039/6012 (2013.01)

Citation (search report)

See references of WO 9940925A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9940925 A2 19990819; WO 9940925 A3 19991021; AR 015237 A1 20010418; AU 2686999 A 19990830; BR 9907912 A 20001024; CA 2320969 A1 19990819; CN 1291105 A 20010411; EP 1054690 A2 20001129; IL 137791 D0 20011031; JP 2002502880 A 20020129; PL 342856 A1 20010716; ZA 9901245 B 19990818

INPADOC legal status


2002-06-05 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20020412

2000-11-29 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000815

2000-11-29 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE