Global Patent Index - EP 1054858 A1

EP 1054858 A1 2000-11-29 - N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS

Title (en)

N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED-ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS

Title (de)

N-HYDROXY-2-(ALKYL,ARYL, ODER HETEROAPYL, SULFANYL,SULFINYL ODER SULFONYL)-3-SUBSTITUIERTE-ALKYL,ARYL ODER HETEROARYLAMIDE, ALS INHIBITOREN DER MATRIXMETALLOPROEINASE

Title (fr)

ALKYLE, ARYLE OU HETEROARYLAMIDES N-HYDROXY-2-(ALKYL, ARYL OU HETEROARYL SULFANYL, SULFINYL OU SULFONYL)-3-SUBSTITUES EN TANT QU'INHIBITEURS DE LA METALLOPROTEINASE MATRICIELLE

Publication

EP 1054858 A1 (EN)

Application

EP 98943392 A

Priority

  • US 9817633 W
  • US 2637298 A

Abstract (en)

[origin: WO9942436A1] Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF- alpha converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF- alpha from membrane bound TNF- alpha precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF- alpha converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having formula (I), wherein R<2> and R<3> form a heterocyclic ring and A is S, S(O), or S(O)2 and R<1> and R<4> are defined herein.

IPC 1-7 (main, further and additional classification)

C07C 239/14; A61K 31/16; C07D 211/20; C07D 241/04

IPC 8 full level (invention and additional information)

C07D 295/08 (2006.01); A61K 31/16 (2006.01); A61K 31/351 (2006.01); A61K 31/381 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/423 (2006.01); A61K 31/426 (2006.01); A61K 31/428 (2006.01); A61K 31/4406 (2006.01); A61K 31/4418 (2006.01); A61K 31/4427 (2006.01); A61K 31/4433 (2006.01); A61K 31/4436 (2006.01); A61K 31/445 (2006.01); A61K 31/4453 (2006.01); A61K 31/4458 (2006.01); A61K 31/4535 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/47 (2006.01); A61K 31/5375 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61P 1/02 (2006.01); A61P 1/04 (2006.01); A61P 1/16 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 13/12 (2006.01); A61P 15/06 (2006.01); A61P 17/00 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); A61P 19/08 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01); C07C 259/06 (2006.01); C07C 317/44 (2006.01); C07C 323/60 (2006.01); C07D 207/12 (2006.01); C07D 209/48 (2006.01); C07D 211/12 (2006.01); C07D 211/20 (2006.01); C07D 211/54 (2006.01); C07D 211/62 (2006.01); C07D 211/66 (2006.01); C07D 213/56 (2006.01); C07D 215/12 (2006.01); C07D 223/02 (2006.01); C07D 241/04 (2006.01); C07D 263/58 (2006.01); C07D 277/20 (2006.01); C07D 277/36 (2006.01); C07D 277/70 (2006.01); C07D 295/092 (2006.01); C07D 307/54 (2006.01); C07D 309/12 (2006.01); C07D 333/28 (2006.01); C07D 333/34 (2006.01); C07D 401/10 (2006.01); C07D 409/04 (2006.01); C07D 409/10 (2006.01)

CPC (invention and additional information)

C07D 295/088 (2013.01); C07D 211/20 (2013.01); C07D 211/54 (2013.01); C07D 211/62 (2013.01)

Citation (search report)

See references of WO 9942436A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9942436 A1 19990826; AU 757719 B2 20030306; AU 9120198 A 19990906; BG 104782 A 20010831; BR 9815781 A 20001107; CA 2320469 A1 19990826; CN 1213021 C 20050803; CN 1291183 A 20010411; EA 003283 B1 20030424; EA 200000849 A1 20010423; EE 200000471 A 20020215; EP 1054858 A1 20001129; GE P20022797 B 20020510; HR P20000543 A2 20010831; HU 0101837 A2 20011028; HU 0101837 A3 20011128; ID 25639 A 20001019; IL 137566 D0 20010724; JP 2002503717 A 20020205; NO 20004093 A 20001003; NO 20004093 D0 20000816; NZ 506184 A 20030530; PL 342548 A1 20010618; SK 12332000 A3 20010212; TR 200002423 T2 20010122

INPADOC legal status


2007-04-13 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1029113

2001-10-04 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20010301

2000-11-29 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000804

2000-11-29 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-11-29 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000804;LT PAYMENT 20000804;LV PAYMENT 20000804;RO PAYMENT 20000804;SI PAYMENT 20000804