Global patent index - EP 1054865 A1

EP 1054865 A1 2000-11-29 - FARNESYL TRANSFERASE INHIBITORS

Title (en)

FARNESYL TRANSFERASE INHIBITORS

Title (de)

FARNESYLTRANSFERASE INHIBITORE

Title (fr)

INHIBITEURS DE LA FARNESYLE TRANSFERASE

Publication

EP 1054865 A1 (EN)

Application

EP 99903834 A

Priority

  • EP 99903834 A
  • EP 98400294 A
  • GB 9900369 W

Abstract (en)

[origin: WO9941235A1] The present invention relates to a compound of formula (1) wherein A is of formula (2), (3), (4), B is phenyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, thienyl, thiazolyl, furyl or oxazolyl, the ring being substituted on ring carbon atoms by R<1> and -(CH2)nR<2>; or B is pyrrolyl, pyrazolyl or imidazolyl, and when A is of formula (2) or (3), B can also be naphthyl substituted by R<1> and -(CH2)nR<2>; R<1> is of the formula -CONHCH(R<10>)R<11> wherein R<11> is of the formula -CH2OR<13>, -COR<14> or -CH2COR<14> or R<11> is morpholinoC1-4alkyl, pyrrolidin-1-ylC1-4alkyl or piperidin-1-ylC1-4alkyl; or R<11> is phenyl-1-hydroxyC1-4alkyl; or heteroaryl-1-hydroxyC1-4alkyl; R<2> is phenyl or heteroaryl; and n is 0, 1 or 2; or a prodrug, solvate or pharmaceutically-acceptable salt thereof. Processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. A particular use is in cancer therapy.

IPC 1-7 (main, further and additional classification)

C07D 207/12; A61K 31/395; C07D 231/12; C07D 401/12; C07D 403/12; C07D 417/06; C07D 417/12

IPC 8 full level (invention and additional information)

C07D 233/56 (2006.01); A61K 31/395 (2006.01); A61K 31/40 (2006.01); A61K 31/41 (2006.01); A61K 31/4164 (2006.01); A61K 31/4196 (2006.01); A61K 31/427 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/5375 (2006.01); A61K 31/551 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 207/12 (2006.01); C07D 231/12 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01); C07D 521/00 (2006.01)

CPC (invention and additional information)

C07D 231/12 (2013.01); C07D 207/12 (2013.01); C07D 233/56 (2013.01); C07D 249/08 (2013.01); C07D 401/12 (2013.01); C07D 417/12 (2013.01)

Citation (search report)

See references of WO 9941235A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9941235 A1 19990819; AU 2435199 A 19990830; EP 1054865 A1 20001129; JP 2002503650 A 20020205; ZA 9901032 B 19991027

INPADOC legal status

2004-01-28 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030724

2003-05-02 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030313

2000-11-29 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000911

2000-11-29 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE