EP 1054865 A1 20001129 - FARNESYL TRANSFERASE INHIBITORS
Title (en)
FARNESYL TRANSFERASE INHIBITORS
Title (de)
FARNESYLTRANSFERASE INHIBITORE
Title (fr)
INHIBITEURS DE LA FARNESYLE TRANSFERASE
Publication
Application
Priority
- EP 99903834 A 19990204
- EP 98400294 A 19980210
- GB 9900369 W 19990204
Abstract (en)
[origin: WO9941235A1] The present invention relates to a compound of formula (1) wherein A is of formula (2), (3), (4), B is phenyl, pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, thienyl, thiazolyl, furyl or oxazolyl, the ring being substituted on ring carbon atoms by R<1> and -(CH2)nR<2>; or B is pyrrolyl, pyrazolyl or imidazolyl, and when A is of formula (2) or (3), B can also be naphthyl substituted by R<1> and -(CH2)nR<2>; R<1> is of the formula -CONHCH(R<10>)R<11> wherein R<11> is of the formula -CH2OR<13>, -COR<14> or -CH2COR<14> or R<11> is morpholinoC1-4alkyl, pyrrolidin-1-ylC1-4alkyl or piperidin-1-ylC1-4alkyl; or R<11> is phenyl-1-hydroxyC1-4alkyl; or heteroaryl-1-hydroxyC1-4alkyl; R<2> is phenyl or heteroaryl; and n is 0, 1 or 2; or a prodrug, solvate or pharmaceutically-acceptable salt thereof. Processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. A particular use is in cancer therapy.
IPC 1-7
C07D 207/12; A61K 31/395; C07D 403/12; C07D 231/12; C07D 417/06; C07D 401/12; C07D 417/12
IPC 8 full level
C07D 233/56 (2006.01); A61K 31/395 (2006.01); A61K 31/40 (2006.01); A61K 31/41 (2006.01); A61K 31/4164 (2006.01); A61K 31/4196 (2006.01); A61K 31/427 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/5375 (2006.01); A61K 31/551 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 207/12 (2006.01); C07D 231/12 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01); C07D 521/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07D 207/12 (2013.01); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 249/08 (2013.01); C07D 401/12 (2013.01); C07D 417/12 (2013.01)
Citation (search report)
See references of WO 9941235A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9941235 A1 19990819; AU 2435199 A 19990830; EP 1054865 A1 20001129; JP 2002503650 A 20020205; ZA 991032 B 19991027
DOCDB simple family (application)
GB 9900369 W 19990204; AU 2435199 A 19990204; EP 99903834 A 19990204; JP 2000531430 A 19990204; ZA 991032 A 19990209