EP 1054876 A1 20001129 - 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS
Title (en)
1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS
Title (de)
1,3,4-THIADIAZOLDERIVATE ALS KYN-OH HEMMER
Title (fr)
DERIVES DE 1,2,3-THIADIAZOLES UTILISES COMME INHIBITEURS DE KYN-OH
Publication
Application
Priority
- EP 9806995 W 19981027
- GB 9725055 A 19971126
Abstract (en)
[origin: WO9928309A1] Compounds of formula (I) wherein m is zero or 1; Q represents a C6-C14 aromatic ring system or an optionally substituted, saturated or unsaturated, heteromonocyclic or heterobicyclic ring containing one or two heteroatoms chosen from oxygen, sulfur and nitrogen X is oxygen or sulfur; Y is oxygen, sulfur or NH; p is 0 or 1; R is CC13, CF3, a N(R7R8) group, in which each of R7 and R8 is independently hydrogen or C1-C6 alkyl or R7 and R8 taken together with the nitrogen atom to which they are linked, form a saturated or unsaturated C5-C7 heterocyclic ring or R is an optionally substituted phenyl or naphthyl ring; R1 is hydrogen, CH2OPO3H2, a -(CH2)n-N(R9R10) group in which n is an integer of 1 to 4 and each of R9 and R10 is independently hydrogen, C1-C6 alkyl or phenyl, or R9 and R10, taken together with the nitrogen atom to which they are linked, form a saturated or unsaturated C5-C7 heterocyclic ring; or R1 is a group of formula (A) wherein X, Y, p and R are independently as defined above; and the pharmaticeutically acceptable salts thereof have kynurenine-3-hydroxylase enzyme inhibitory activity.
IPC 1-7
C07D 285/12; A61K 31/41; C07D 401/12; A61K 31/44; C07D 403/12; C07D 403/04; A61K 31/55
IPC 8 full level
A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 285/135 (2006.01); C07D 417/04 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 417/12 (2006.01); C07D 521/00 (2006.01); C07F 9/6539 (2006.01); C07D 285/12 (2006.01)
CPC (source: EP)
A61K 31/433 (2013.01); A61P 9/10 (2017.12); A61P 25/00 (2017.12); A61P 25/08 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 249/08 (2013.01); C07D 285/135 (2013.01); C07D 417/04 (2013.01); C07F 9/65395 (2013.01)
Citation (search report)
See references of WO 9928309A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9928309 A1 19990610; AU 1487599 A 19990616; CA 2310008 A1 19990610; EP 1054876 A1 20001129; GB 9725055 D0 19980128; JP 2001524547 A 20011204
DOCDB simple family (application)
EP 9806995 W 19981027; AU 1487599 A 19981027; CA 2310008 A 19981027; EP 98958896 A 19981027; GB 9725055 A 19971126; JP 2000523201 A 19981027