Global patent index - EP 1054876 A1

EP 1054876 A1 2000-11-29 - 1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS

Title (en)

1,3,4-THIADIAZOLES DERIVATIVES AS KYN-OH INHIBITORS

Title (de)

1,3,4-THIADIAZOLDERIVATE ALS KYN-OH HEMMER

Title (fr)

DERIVES DE 1,2,3-THIADIAZOLES UTILISES COMME INHIBITEURS DE KYN-OH

Publication

EP 1054876 A1 (EN)

Application

EP 98958896 A

Priority

  • EP 9806995 W
  • GB 9725055 A

Abstract (en)

[origin: WO9928309A1] Compounds of formula (I) wherein m is zero or 1; Q represents a C6-C14 aromatic ring system or an optionally substituted, saturated or unsaturated, heteromonocyclic or heterobicyclic ring containing one or two heteroatoms chosen from oxygen, sulfur and nitrogen X is oxygen or sulfur; Y is oxygen, sulfur or NH; p is 0 or 1; R is CC13, CF3, a N(R7R8) group, in which each of R7 and R8 is independently hydrogen or C1-C6 alkyl or R7 and R8 taken together with the nitrogen atom to which they are linked, form a saturated or unsaturated C5-C7 heterocyclic ring or R is an optionally substituted phenyl or naphthyl ring; R1 is hydrogen, CH2OPO3H2, a -(CH2)n-N(R9R10) group in which n is an integer of 1 to 4 and each of R9 and R10 is independently hydrogen, C1-C6 alkyl or phenyl, or R9 and R10, taken together with the nitrogen atom to which they are linked, form a saturated or unsaturated C5-C7 heterocyclic ring; or R1 is a group of formula (A) wherein X, Y, p and R are independently as defined above; and the pharmaticeutically acceptable salts thereof have kynurenine-3-hydroxylase enzyme inhibitory activity.

IPC 1-7 (main, further and additional classification)

C07D 285/12; A61K 31/41; A61K 31/44; A61K 31/55; C07D 401/12; C07D 403/04; C07D 403/12

IPC 8 full level (invention and additional information)

A61K 31/433 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01); A61P 9/10 (2006.01); A61P 25/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07D 285/135 (2006.01); C07D 417/04 (2006.01); C07D 417/06 (2006.01); C07D 417/10 (2006.01); C07D 417/12 (2006.01); C07D 521/00 (2006.01); C07F 9/6539 (2006.01); C07D 285/12 (2006.01)

CPC (invention and additional information)

C07D 285/135 (2013.01); A61K 31/433 (2013.01); C07D 231/12 (2013.01); C07D 233/56 (2013.01); C07D 249/08 (2013.01); C07D 417/04 (2013.01); C07F 9/65395 (2013.01)

Citation (search report)

See references of WO 9928309A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9928309 A1 19990610; AU 1487599 A 19990616; CA 2310008 A1 19990610; EP 1054876 A1 20001129; GB 9725055 D0 19980128; JP 2001524547 A 20011204

INPADOC legal status

2001-04-25 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20010223

2000-11-29 [17P] REQUEST FOR EXAMINATION FILED

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- Effective date: 20000530

2000-11-29 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-11-29 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

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- Free Format Text: AL PAYMENT 20000530;LT PAYMENT 20000530;LV PAYMENT 20000530;MK PAYMENT 20000530;RO PAYMENT 20000530;SI PAYMENT 20000530