EP 1054896 A1 20001129 - ANALGESIC PEPTIDES FROM VENOM OF GRAMMOSTOLA SPATULATA AND USE THEREOF
Title (en)
ANALGESIC PEPTIDES FROM VENOM OF GRAMMOSTOLA SPATULATA AND USE THEREOF
Title (de)
ANALGETISCHE PEPTIDE VOM GIFT DER GRAMMOSTOLA SPATULATA UND DEREN VERWENDUNG
Title (fr)
PEPTIDES ANALGESIQUES EXTRAITS DU VENIN DE LA GRAMMOSTOLA SPATULATA ET LEUR UTILISATION
Publication
Application
Priority
GB 9800534 W 19980220
Abstract (en)
[origin: WO9942480A1] The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence Tyr-Cys-Gln-Lys-Trp-Leu-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Arg -Leu-NH2 (SEQ ID NO:1) or Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Glu-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Leu-Val-Cys-Arg-Leu -Trp-Cys-Lys-Lys-Lys-Ile-Glu-Trp (SEQ ID NO:2). The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO:1. The peptides of SEQ ID NO:1 and SEQ ID NO:2 can also be used in methods for identifying compounds having analgesia-inducing activity.
IPC 1-7
IPC 8 full level
A61K 38/16 (2006.01); A61K 39/395 (2006.01); A61P 31/04 (2006.01); C07K 14/435 (2006.01); C07K 16/18 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07K 14/43518 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 9942480A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9942480 A1 19990826; AU 6109698 A 19990906; CA 2319038 A1 19990826; EP 1054896 A1 20001129; JP 2002509080 A 20020326
DOCDB simple family (application)
GB 9800534 W 19980220; AU 6109698 A 19980220; CA 2319038 A 19980220; EP 98905534 A 19980220; JP 2000532432 A 19980220