EP 1054899 A2 20001129 - AGENTS FOR TREATING HUMAN ILLNESSES BASED ON $g(b)-CATENIN, AND THE PRODUCTION AND USE THEREOF
Title (en)
AGENTS FOR TREATING HUMAN ILLNESSES BASED ON $g(b)-CATENIN, AND THE PRODUCTION AND USE THEREOF
Title (de)
MITTEL ZUR THERAPIE VON MENSCHLICHEN ERKRANKUNGEN, AUSGEHEND VON BETA-CATENIN, SEINE HERSTELLUNG UND SEINE VERWENDUNG
Title (fr)
MOYEN DE TRAITEMENT DE PATHOLOGIES HUMAINES A PARTIR DE LA $g(b)-CATENINE, ET SON UTILISATION
Publication
Application
Priority
- DE 9900554 W 19990222
- DE 19807390 A 19980221
Abstract (en)
[origin: DE19909251A1] Agent (A) for treating human disease is based on substances (I) that modulate (inhibit or promote) the interaction of beta -catenin (bC) with transcription factors or products of tumor suppressor genes. Independent claims are also included for the following: (a) peptide (II) comprising part of the LEF-1/TCF-4 transcription factors, or their variants and mutants; (b) peptide and related molecules (III) from the armadillo domain (arm units 3-8) of bC, and mutants of the complete bC molecule, that include at least one of the specific interaction domains for LEF-1, TCF-4, APC, conductin or E-cadherin; and (c) enzyme-linked immunosorbent assay (ELISA) for screening substance libraries for compounds that modulate interaction of bC with LEF-1/TCF, APC, conductin or E-cadherin.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 17/14 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 19/00 (2006.01); G01N 33/53 (2006.01); G01N 33/543 (2006.01)
CPC (source: EP US)
A61P 17/14 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/4702 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9942481A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
DE 19909251 A1 19990826; CA 2357015 A1 19990826; EP 1054899 A2 20001129; JP 2002505255 A 20020219; US 7067474 B1 20060627; WO 9942481 A2 19990826; WO 9942481 A3 20000210
DOCDB simple family (application)
DE 19909251 A 19990222; CA 2357015 A 19990222; DE 9900554 W 19990222; EP 99913097 A 19990222; JP 2000532433 A 19990222; US 64110400 A 20000817