EP 1054905 A1 20001129 - DERIVATISED ANTIBODIES WITH EXPOSED CARBOHYDRATE CHAINS CAPABLE OF BINDING TO IMMOBILISED IGG

Title (en)

DERIVATISED ANTIBODIES WITH EXPOSED CARBOHYDRATE CHAINS CAPABLE OF BINDING TO IMMOBILISED IGG

Title (de)

DERIVATISIERTE ANTIKÖRPER MIT EXPONIERTEN KOHLENHYDRATKETTEN FÄHIG ZUR BINDUNG AN IMMOBILISIERTES IGG

Title (fr)

ANTICORPS DERIVATISES COMPORTANT DES CHAINES DE GLUCIDES EXPOSEES, CAPABLES DE SE FIXER SUR DES IgG IMMOBILISEES

Publication

EP 1054905 A1 20001129 (EN)

Application

EP 99904976 A 19990205

Priority

GB 9900385 W 19990205
GB 9803257 A 19980216

Abstract (en)

[origin: WO9941286A1] A method of derivatising antibodies to expose carbohydrate chains so that the antibodies are capable of binding to immobilised IgG, such as agalactosyl IgG, is disclosed. The derivatised antibodies are useful in the diagnosis and treatment of conditions associated with immobilised IgG, such as rheumatoid arthritis (RA), in a preferred embodiment providing a non-invasive technique which can detect the immobilised IgG in situ, thereby assisting in the diagnosis or treatment of conditions associated with it, such as autoimmune disorders including rheumatoid arthritis, juvenile arthritis, Crohn's disease, type I insulin dependent diabetes, type II diabetes, sarcoidosis, erythema nodosum leprosum and tuberculosis, and especially in the diagnosis of erosive joint disease.

IPC 1-7

C07K 16/42; C07K 16/00

IPC 8 full level

A61K 39/395 (2006.01); A61P 1/04 (2006.01); A61P 3/10 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 31/06 (2006.01); A61P 31/08 (2006.01); A61P 37/00 (2006.01); C07K 16/00 (2006.01); C07K 16/42 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

A61P 1/04 (2017.12); A61P 3/10 (2017.12); A61P 19/02 (2017.12); A61P 29/00 (2017.12); A61P 31/06 (2017.12); A61P 31/08 (2017.12); A61P 37/00 (2017.12); C07K 16/00 (2013.01); C07K 16/4283 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9941286A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9941286 A1 19990819; AU 2529199 A 19990830; AU 742074 B2 20011213; CA 2321277 A1 19990819; EP 1054905 A1 20001129; GB 9803257 D0 19980408; JP 2002503677 A 20020205

DOCDB simple family (application)

GB 9900385 W 19990205; AU 2529199 A 19990205; CA 2321277 A 19990205; EP 99904976 A 19990205; GB 9803257 A 19980216; JP 2000531477 A 19990205