EP 1054954 A1 20001129 - DEVELOPMENT OF REGULATORY CELLS AS A MEANS FOR TREATING AUTOIMMUNE DISEASE
Title (en)
DEVELOPMENT OF REGULATORY CELLS AS A MEANS FOR TREATING AUTOIMMUNE DISEASE
Title (de)
ENTWICKLUNG VON REGULIERENDEN ZELLEN ALS MITTEL FÜR BEHANDLUNG VON AUTOIMMUNKRANKHEITEN
Title (fr)
MISE AU POINT DE CELLULES DE REGULATION COMME INSTRUMENT DE TRAITEMENT DE MALADIES AUTO-IMMUNES
Publication
Application
Priority
- CA 9900069 W 19990128
- US 7285898 P 19980128
- US 7287798 P 19980128
Abstract (en)
[origin: WO9938953A1] A population of mammalian T-cells enriched in cells which have a cytokine production profile characteristic of Th2-like cells (IL-4 production, etc.) is produced by culturing T-cells, including thymocytes, in a conditioned medium (CM), which is prepared by culturing mammalian cells such as peripheral blood cells in the presence of plant mitogens. The proliferation and differentiation to single positive T-cells is promoted by the presence of IL-4 in the culture medium. The enriched population of IL-4 producing T-cells according to the invention show potential use as a source of cells for cell therapy in treating IL-4 response related disorders including certain autoimmune conditions such as diabetes mellitus.
IPC 1-7
IPC 8 full level
A61K 39/00 (2006.01); C12N 5/06 (2006.01); C12N 5/071 (2010.01); C12N 5/078 (2010.01); C12N 5/08 (2006.01); A61K 35/12 (2006.01)
CPC (source: EP)
A61K 39/0008 (2013.01); C12N 5/0648 (2013.01); C12N 5/065 (2013.01); A61K 2035/122 (2013.01); A61K 2039/57 (2013.01); C12N 2501/59 (2013.01); C12N 2502/11 (2013.01)
Citation (search report)
See references of WO 9938953A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9938953 A1 19990805; AU 2260699 A 19990816; AU 756716 B2 20030123; CA 2319666 A1 19990805; EP 1054954 A1 20001129
DOCDB simple family (application)
CA 9900069 W 19990128; AU 2260699 A 19990128; CA 2319666 A 19990128; EP 99902470 A 19990128