EP 1054969 A2 20001129 - RETINOBLASTOMA PROTEIN COMPLEXES AND RETINOBLASTOMA INTERACTING PROTEINS
Title (en)
RETINOBLASTOMA PROTEIN COMPLEXES AND RETINOBLASTOMA INTERACTING PROTEINS
Title (de)
RETINOBLASTOMPROTEIN KOMPLEXE UND PROTEINE DIE MIT DEM RETINOBLASTOMPROTEIN WECHSEL WIRKEN
Title (fr)
COMPLEXES PROTEIQUES DE RETINOBLASTOME ET PROTEINES INTERAGISSANT AVEC LE RETINOBLASTOME
Publication
Application
Priority
- US 9903072 W 19990212
- US 7455998 P 19980212
- US 24896099 A 19990211
Abstract (en)
[origin: WO9941376A2] The present invention relates to complexes of the retinoblastoma (RB) protein with proteins identified as interacting with RB by an improved, modified yeast two hybrid assay system. The proteins identified to interact with RB are RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392*. Thus, the present invention provides complexes of RB and RN-tre, CAS, IP-30, L6, IK, LDH-B, Nlk1(Nek 2), cyclophilin A, Zap 3, CD24*, Set*, GluT1*, and 115392* and derivatives, fragments and analogs thereof. The invention also provides the CD24*, Set*, GluT1*, and 115392* genes and proteins and derivatives, fragments and analogs thereof. Methods of screening the complexes for efficacy in treating and/of preventing certain diseases and disorders, particularly hyperproliferative disorders, including cancer, neurodegenerative disease, and viral disease, are also disclosed herein.
IPC 1-7
C12N 15/12; C07K 14/47; C12N 15/62; C07K 16/18; A61K 38/16; G01N 33/68; A01K 67/027; C12N 15/11; A61K 48/00
IPC 8 full level
A01K 67/027 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/04 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/4736 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01); C07K 2319/02 (2013.01)
Citation (search report)
See references of WO 9941376A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9941376 A2 19990819; WO 9941376 A3 20000210; WO 9941376 A8 20001012; WO 9941376 A9 20010201; CA 2319782 A1 19990819; EP 1054969 A2 20001129; JP 2002503466 A 20020205
DOCDB simple family (application)
US 9903072 W 19990212; CA 2319782 A 19990212; EP 99932509 A 19990210; JP 2000531557 A 19990212