Global Patent Index - EP 1054976 A1

EP 1054976 A1 2000-11-29 - METHODS FOR DESIGNING INHIBITORS OF SERINE/THREONINE KINASES AND TYROSINE KINASES

Title (en)

METHODS FOR DESIGNING INHIBITORS OF SERINE/THREONINE KINASES AND TYROSINE KINASES

Title (de)

VERFAHREN ZUR ENTWICKLUNG VON SERINE/THREONINE KINASE UND TYROSINE KINASE INHIBITOREN

Title (fr)

PROCEDES SERVANT A DEVELOPPER DES INHIBITEURS DE SERINE/THREONINE KINASES ET DE TYROSINE KINASES

Publication

EP 1054976 A1 (EN)

Application

EP 99907020 A

Priority

  • US 9903181 W
  • US 2558098 A

Abstract (en)

[origin: WO9942592A1] The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.

IPC 1-7 (main, further and additional classification)

C12N 15/54; C12N 9/12; C12Q 1/48

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C12N 9/12 (2006.01); C12N 9/99 (2006.01); C12N 15/54 (2006.01); C12Q 1/48 (2006.01)

CPC (invention and additional information)

C12N 9/1205 (2013.01); G01N 2333/9121 (2013.01)

Citation (search report)

See references of WO 9942592A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9942592 A1 19990826; AU 2679099 A 19990906; CA 2321184 A1 19990826; EP 1054976 A1 20001129; JP 2002504339 A 20020212; US 2003165899 A1 20030904; US 2004259166 A1 20041223; US 6162613 A 20001219; US 6849716 B1 20050201; ZA 9901225 B 20000816

INPADOC legal status


2010-09-30 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1034095

2007-08-08 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SU, MICHAEL, S.

2007-08-08 [RIN1] INVENTOR (CORRECTION)

- Inventor name: FOX, EDWARD

2007-08-08 [RIN1] INVENTOR (CORRECTION)

- Inventor name: WILSON, KEITH P.

2007-08-08 [RIN1] INVENTOR (CORRECTION)

- Inventor name: GERMANN, URSULA, A.

2006-05-24 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051106

2005-06-08 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050425

2001-04-04 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SU, MICHAEL, S.

2001-04-04 [RIN1] INVENTOR (CORRECTION)

- Inventor name: FOX, EDWARD

2001-04-04 [RIN1] INVENTOR (CORRECTION)

- Inventor name: WILSON, KEITH P.

2001-04-04 [RIN1] INVENTOR (CORRECTION)

- Inventor name: GERMANN, URSULA, A.

2000-11-29 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000823

2000-11-29 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE