EP 1054976 A1 20001129 - METHODS FOR DESIGNING INHIBITORS OF SERINE/THREONINE KINASES AND TYROSINE KINASES
Title (en)
METHODS FOR DESIGNING INHIBITORS OF SERINE/THREONINE KINASES AND TYROSINE KINASES
Title (de)
VERFAHREN ZUR ENTWICKLUNG VON SERINE/THREONINE KINASE UND TYROSINE KINASE INHIBITOREN
Title (fr)
PROCEDES SERVANT A DEVELOPPER DES INHIBITEURS DE SERINE/THREONINE KINASES ET DE TYROSINE KINASES
Publication
Application
Priority
- US 9903181 W 19990216
- US 2558098 A 19980218
Abstract (en)
[origin: WO9942592A1] The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); C12N 9/12 (2006.01); C12N 9/99 (2006.01); C12N 15/54 (2006.01); C12Q 1/48 (2006.01)
CPC (source: EP US)
C12N 9/1205 (2013.01 - EP US); G01N 2333/9121 (2013.01 - EP US)
Citation (search report)
See references of WO 9942592A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9942592 A1 19990826; AU 2679099 A 19990906; CA 2321184 A1 19990826; EP 1054976 A1 20001129; JP 2002504339 A 20020212; US 2003165899 A1 20030904; US 2004259166 A1 20041223; US 6162613 A 20001219; US 6849716 B1 20050201; ZA 991225 B 20000816
DOCDB simple family (application)
US 9903181 W 19990216; AU 2679099 A 19990216; CA 2321184 A 19990216; EP 99907020 A 19990216; JP 2000532532 A 19990216; US 17066302 A 20020612; US 2558098 A 19980218; US 64274900 A 20000818; US 89307204 A 20040715; ZA 991225 A 19990216