EP 1056718 A1 20001206 - ANTI-RETROVIRAL FUNCTIONALISED AROMATIC COMPOUNDS

Title (en)

ANTI-RETROVIRAL FUNCTIONALISED AROMATIC COMPOUNDS

Title (de)

ANTIRETROVIRALE FUNKTIONALISIERTE AROMATISCHE VERBINDUNGEN

Title (fr)

COMPOSES AROMATIQUES FONCTIONNALISES ANTI-RETROVIRAUX

Publication

EP 1056718 A1 20001206 (FR)

Application

EP 99903779 A 19990218

Priority

FR 9900363 W 19990218
FR 9802106 A 19980220

Abstract (en)

[origin: FR2775286A1] Triphenylene derivatives carrying at least one hydrocarbon substituent having at least one H atom and at least one group capable of hydrogen bonding with the protein Tat (Trans-Acting Transcriptional activator) through a proton donor or acceptor group. The triphenylene derivatives are of formula (I) are new. A, B, and C = hydrocarbon substituents, each having at least one H atom and at least one group capable of hydrogen bonding with the protein Tat The group B is preferably a non-functionalized linear aliphatic chain having at its extremity at least 2 doublet acceptor functions, more preferably a 1-8 atom (especially 4-8 atoms) linear aliphatic chain (possibly containing 1 or 2 heteroatoms) with 2 doublet acceptor functionalities in the same plain (most preferably the doublet acceptors are carbonyls). Most preferred are 5-(2,5-dioxo-cyclopentyl)-n-pentyl or 5-(3,4-dihydro-2,5-dioxo 1H-pyrrol-1-yl)-n-pentyl. A and C are preferably either 1-4C aliphatic groups, or they carry at least one proton donor or acceptor group.

IPC 1-7

C07D 207/44; C07D 401/10; A61K 31/445; A61K 31/40

IPC 8 full level

A61K 31/122 (2006.01); A61K 31/4015 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61P 31/12 (2006.01); C07D 207/40 (2006.01); C07D 207/444 (2006.01); C07D 207/448 (2006.01); C07D 401/10 (2006.01); C07D 207/44 (2006.01)

CPC (source: EP)

A61P 31/12 (2017.12); C07D 207/448 (2013.01); C07D 401/10 (2013.01)

Citation (search report)

See references of WO 9942441A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

FR 2775286 A1 19990827; FR 2775286 B1 20010907; CA 2321219 A1 19990826; EP 1056718 A1 20001206; JP 2002503719 A 20020205; WO 9942441 A1 19990826

DOCDB simple family (application)

FR 9802106 A 19980220; CA 2321219 A 19990218; EP 99903779 A 19990218; FR 9900363 W 19990218; JP 2000532393 A 19990218