Global Patent Index - EP 1056727 A1

EP 1056727 A1 2000-12-06 - SOLID SUPPORT SYNTHESIS OF 2-OXOPIPERAZINES

Title (en)

SOLID SUPPORT SYNTHESIS OF 2-OXOPIPERAZINES

Title (de)

FESTSTÜTZE SYNTHESE VON 2-OXOPIPERAZINEN

Title (fr)

SYNTHESE DE 2-OXOPIPERAZINES SUR SUPPORT SOLIDE

Publication

EP 1056727 A1 (EN)

Application

EP 99905883 A

Priority

  • US 9902734 W
  • US 7613098 P

Abstract (en)

[origin: WO9943662A1] The subject invention involves processes for making 2-oxopiperazine and homologous compounds using a solid support resin by (a) removing the protecting group from an N-protected amino acid ester of the resin (if present), (b) reacting the resulting unprotected resin ester with a N-protected alpha -amino aldehyde, (c) optionally modifying the resulting intermediate by substituting a non-hydrogen moiety on the N from the amino acid, (d) removing the remaining N-protecting group from the N from the amino aldehyde, and (e) cleaving/cyclizing the product from the resin.

IPC 1-7 (main, further and additional classification)

C07D 241/08; C07D 243/08

IPC 8 full level (invention and additional information)

C07D 241/08 (2006.01); C07D 243/08 (2006.01); C07D 245/02 (2006.01)

CPC (invention and additional information)

C07D 243/08 (2013.01); C07D 241/08 (2013.01); Y02P 20/55 (2015.11)

Citation (search report)

See references of WO 9943662A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9943662 A1 19990902; AU 2593999 A 19990915; CA 2321302 A1 19990902; EP 1056727 A1 20001206; IL 137918 D0 20011031; JP 2002504545 A 20020212; NO 20004278 A 20000825; NO 20004278 D0 20000825

INPADOC legal status


2004-03-03 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030902

2000-12-06 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000919

2000-12-06 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE