Title (en)

METHODS AND COMPOSITIONS USING TUMOR SPECIFIC SOLUBLE INTERLEUKIN-2 RECEPTOR ALPHA MOLECULES

Title (de)

VERFAHREN UND ZUSAMMENSETZUNGEN MIT TUMORSPEZIFISCHEN LÖSLICHEN INTERLEUKIN-2-REZEPTOR ALPHA MOLEKÜLEN

Title (fr)

PROCEDES ET COMPOSITIONS FAISANT INTERVENIR DES MOLECULES DE RECEPTEUR DE L'INTERLEUKINE 2 CHAINE ALPHA SOLUBLE (tsIL-2R$g(a)) SPECIFIQUES DES TUMEURS

Publication

EP 1056841 A1 20001206 (EN)

Application

EP 99908520 A 19990226

Priority

• US 9904222 W 19990226
• US 7613598 P 19980227
• US 25731699 A 19990225

Abstract (en)

[origin: WO9943798A1] Provided are compositions comprising soluble IL-2R alpha molecules (tsIL-2R alpha ) produced and shed by metastatic cells; nucleic acid molecules encoding tsIL-2R alpha , vectors for expressing tsIL-2R alpha ; assay kits for detecting and quantitating the amount of tsIL-2R alpha in a sample; and methods for detecting and quantitating the amount of tsIL-2R alpha that may be present in a body fluid of an individual. A method for detecting the presence or absence of tsIL-2R alpha in a body fluid of an individual comprises obtaining a sample of body fluid from the individual; contacting the sample with an affinity ligand which binds to an epitope on tsIL-2R alpha ; and detecting the amount of tsIL-2R alpha bound to the affinity ligand.

IPC 1-7

C12N 15/00; C12N 15/11; C12N 1/00; C12N 15/03; C12N 15/63; C12Q 1/68; G01N 33/50; C07K 1/00; C07K 14/715; A61K 38/00

IPC 8 full level

C07K 14/715 (2006.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP)

C07K 14/7155 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5091 (2013.01); C12Q 2600/112 (2013.01); G01N 2333/715 (2013.01)

Citation (search report)

See references of WO 9943798A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9943798 A1 19990902; AU 2793099 A 19990915; EP 1056841 A1 20001206

DOCDB simple family (application)

US 9904222 W 19990226; AU 2793099 A 19990226; EP 99908520 A 19990226