Global Patent Index - EP 1056854 A2

EP 1056854 A2 2000-12-06 - PROTEASE-ACTIVATED RECEPTOR 4 AND USES THEREOF

Title (en)

PROTEASE-ACTIVATED RECEPTOR 4 AND USES THEREOF

Title (de)

PROTEASE-AKTIVIERTER REZEPTOR 4 UND VERWENDUNG DAVON

Title (fr)

RECEPTEUR 4 ACTIVE PAR LA PROTEASE ET SES UTILISATIONS

Publication

EP 1056854 A2 (EN)

Application

EP 99906934 A

Priority

  • US 9902983 W
  • US 3239798 A

Abstract (en)

[origin: WO9943809A2] Disclosed are cDNAs and genomic DNAs encoding protease-activated receptor 4 (PAR4) from mouse and human, and the recombinant polypeptides expressed from such cDNAs. The recombinant receptor polypeptides, receptor fragments and analogs expressed on the surface of cells are used in methods of screening candidate compounds for their ability to act as agonists or antagonists to the effects of interaction between thrombin and PAR4. Agonists are used as therapeutics to treat wounds, promote clotting, and as reagents to activate platelets in diagnostic tests. Antagonists are used as therapeutics to control blood coagulation, treat heart attack and stroke, and block inflammatory and proliferative responses to injury as occur in normal wound healing and variety of diseases including atherosclerosis, restenosis, pulmonary inflammation (ARDS) and glomerulosclerosis. Antibodies specific for a protease-activated receptor 4 (or receptor fragment or analog) and their use as a therapeutic are also disclosed.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 38/17; A61K 38/48; C07K 14/705; C07K 16/28; C12N 1/19; C12N 1/21; C12N 5/10; C12N 9/74; C12Q 1/00; G01N 33/68

IPC 8 full level (invention and additional information)

G01N 33/68 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 7/02 (2006.01); A61P 9/10 (2006.01); A61P 17/02 (2006.01); A61P 29/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 9/74 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12Q 1/00 (2006.01)

CPC (invention and additional information)

C12N 9/6429 (2013.01); C07K 14/705 (2013.01); C12Y 304/21005 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9943809A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9943809 A2 19990902; WO 9943809 A3 19991014; AU 2672899 A 19990915; CA 2321142 A1 19990902; EP 1056854 A2 20001206; JP 2002504369 A 20020212; NO 20004274 A 20001013; NO 20004274 D0 20000825

INPADOC legal status


2005-03-09 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20040901

2001-04-25 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: COUGHLIN, SHAUN, R.

2001-04-25 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: KAHN, MARK

2000-12-06 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000925

2000-12-06 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE