EP 1056879 A1 20001206 - SELF-REPLICATING VECTOR FOR DNA IMMUNIZATION AGAINST HIV

Title (en)

SELF-REPLICATING VECTOR FOR DNA IMMUNIZATION AGAINST HIV

Title (de)

SELBST-REPLIZIERENDE VEKTOREN, FÜR DNA IMMUNISIERUNG GEGEN HIV

Title (fr)

VECTEUR AUTOREPRODUCTEUR POUR L'IMMUNISATION PAR L'ADN CONTRE LE VIH

Publication

EP 1056879 A1 20001206 (EN)

Application

EP 99906279 A 19990226

Priority

FI 9900152 W 19990226
FI 980463 A 19980227

Abstract (en)

[origin: WO9943841A1] A nucleotide sequence encoding the HIV regulatory protein NEF, REV or TAT or an immunologically active fragment thereof is inserted into a vector comprising papilloma virus nucleotide sequences necessary and sufficient for long-term persistence. The resulting vectors are self-replicating and have a high copy number. They express the HIV genes in high amounts for a long period of time. The vectors elicit both a humoral and cell-mediated immune response and are therefore potential DNA immunization vaccines against HIV. The invention is directed to said vectors and vaccines and to a method for preparing the vectors. The invention is further directed to a host cell comprising the vector, to the use of the vector in the manufacture of a vaccine and to a method of preventing or treating HIV.

IPC 1-7

C12N 15/86; C12N 15/49; A61K 48/00

IPC 8 full level

C12N 15/79 (2006.01); A61P 31/18 (2006.01); C07K 14/16 (2006.01); C12N 15/48 (2006.01); C12N 15/49 (2006.01); C12N 15/85 (2006.01); A61K 39/00 (2006.01); C12N 15/63 (2006.01)

CPC (source: EP)

A61P 31/18 (2018.01); C07K 14/005 (2013.01); C12N 15/85 (2013.01); A61K 39/00 (2013.01); A61K 2039/51 (2013.01); C12N 2740/16322 (2013.01); C12N 2800/108 (2013.01); C12N 2830/42 (2013.01); C12N 2840/20 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9943841 A1 19990902; AP 2000001892 A0 20000930; AU 2626699 A 19990915; CN 1295623 A 20010516; EP 1056879 A1 20001206; FI 105105 B 20000615; FI 980463 A0 19980227; FI 980463 A 19990927; OA 11528 A 20040507; RU 2232815 C2 20040720

DOCDB simple family (application)

FI 9900152 W 19990226; AP 2000001892 A 19990226; AU 2626699 A 19990226; CN 99804629 A 19990226; EP 99906279 A 19990226; FI 980463 A 19980227; OA 1200000232 A 19990226; RU 2000122617 A 19990226