Global Patent Index - EP 1056879 A1

EP 1056879 A1 2000-12-06 - SELF-REPLICATING VECTOR FOR DNA IMMUNIZATION AGAINST HIV

Title (en)

SELF-REPLICATING VECTOR FOR DNA IMMUNIZATION AGAINST HIV

Title (de)

SELBST-REPLIZIERENDE VEKTOREN, FÜR DNA IMMUNISIERUNG GEGEN HIV

Title (fr)

VECTEUR AUTOREPRODUCTEUR POUR L'IMMUNISATION PAR L'ADN CONTRE LE VIH

Publication

EP 1056879 A1 (EN)

Application

EP 99906279 A

Priority

  • FI 9900152 W
  • FI 980463 A

Abstract (en)

[origin: WO9943841A1] A nucleotide sequence encoding the HIV regulatory protein NEF, REV or TAT or an immunologically active fragment thereof is inserted into a vector comprising papilloma virus nucleotide sequences necessary and sufficient for long-term persistence. The resulting vectors are self-replicating and have a high copy number. They express the HIV genes in high amounts for a long period of time. The vectors elicit both a humoral and cell-mediated immune response and are therefore potential DNA immunization vaccines against HIV. The invention is directed to said vectors and vaccines and to a method for preparing the vectors. The invention is further directed to a host cell comprising the vector, to the use of the vector in the manufacture of a vaccine and to a method of preventing or treating HIV.

IPC 1-7 (main, further and additional classification)

C12N 15/86; A61K 48/00; C12N 15/49

IPC 8 full level (invention and additional information)

C12N 15/79 (2006.01); A61P 31/18 (2006.01); C07K 14/16 (2006.01); C12N 15/48 (2006.01); C12N 15/49 (2006.01); C12N 15/85 (2006.01); A61K 39/00 (2006.01); C12N 15/63 (2006.01)

CPC (invention and additional information)

C07K 14/005 (2013.01); C12N 15/85 (2013.01); A61K 39/00 (2013.01); A61K 2039/51 (2013.01); C12N 2740/16322 (2013.01); C12N 2800/108 (2013.01); C12N 2830/42 (2013.01); C12N 2840/20 (2013.01)

Citation (search report)

See references of WO 9943841A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9943841 A1 19990902; AP 200001892 A0 20000930; AU 2626699 A 19990915; CN 1295623 A 20010516; EP 1056879 A1 20001206; FI 105105 B 20000615; FI 980463 A0 19980227; FI 980463 A 19990927; OA 11528 A 20040507; RU 2232815 C2 20040720

INPADOC legal status


2004-09-29 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040324

2004-01-07 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031113

2000-12-06 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000922

2000-12-06 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-12-06 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: LT PAYMENT 20000922;LV PAYMENT 20000922;SI PAYMENT 20000922