Global Patent Index - EP 1058550 A1

EP 1058550 A1 2000-12-13 - SUBSTITUTED SEMICARBAZIDES AND THE USE THEREOF

Title (en)

SUBSTITUTED SEMICARBAZIDES AND THE USE THEREOF

Title (de)

SUBSTITUIERTE SEMICARBAZIDE UND DEREN VERWENDUNG

Title (fr)

SEMICARBAZIDES SUBSTITUES ET LEUR UTILISATION

Publication

EP 1058550 A1 (EN)

Application

EP 99905734 A

Priority

  • US 9902419 W
  • US 7371098 P

Abstract (en)

[origin: WO9939712A1] This invention is related to substituted semicarbazides represented by Formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; R3, R4, R5 and R6 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl, or R3 and R4 is defined as above, and R5 and R6 together with the nitrogen atom to which they are attached form a heterocycle, including piperidine, piperazine, morpholine; A1 and A2 are independently aryl, heteroaryl, saturated or partially unsaturated carbocycle or satured or partially unsaturated heterocycle, any of which is optionally substituted; X is one of O, S, NR7, CH2, C(O), NR7C(O), C(O)NR7, SO, SO2 or a covalent bond; where R7 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; n is 0, 1, 2 or 3. m is 0, 1, 2 or 3. The invention also is directed to the use of substituted semicarbazides for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as anticonvulsants, and as antimanic depressants, as anti-migraine agents, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.

IPC 1-7 (main, further and additional classification)

A61K 31/535; C07D 207/04; C07D 207/08; C07D 211/70; C07D 215/38; C07D 251/00; C07D 265/30; C07D 307/02; C07D 315/00; C07D 401/00; C07D 413/00

IPC 8 full level (invention and additional information)

C07D 251/12 (2006.01); A61K 31/175 (2006.01); A61K 31/341 (2006.01); A61K 31/351 (2006.01); A61K 31/357 (2006.01); A61K 31/36 (2006.01); A61K 31/381 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/505 (2006.01); A61K 31/53 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); A61P 23/02 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 25/24 (2006.01); C07C 281/06 (2006.01); C07D 215/20 (2006.01); C07D 239/26 (2006.01); C07D 239/34 (2006.01); C07D 239/38 (2006.01); C07D 239/42 (2006.01); C07D 307/02 (2006.01); C07D 307/38 (2006.01); C07D 307/42 (2006.01); C07D 307/52 (2006.01); C07D 307/54 (2006.01); C07D 307/56 (2006.01); C07D 307/58 (2006.01); C07D 307/66 (2006.01); C07D 307/68 (2006.01); C07D 309/12 (2006.01); C07D 317/64 (2006.01)

CPC (invention and additional information)

C07C 281/06 (2013.01)

Designated contracting state (EPC)

BE CH DE ES FR GB IE IT LI NL

EPO simple patent family

WO 9939712 A1 19990812; WO 9939712 A9 19991021; AU 2583199 A 19990823; AU 754681 B2 20021121; CA 2319484 A1 19990812; EP 1058550 A1 20001213; EP 1058550 A4 20021218; IL 137671 D0 20011031; JP 2002511387 A 20020416; MX PA00007585 A 20021017

INPADOC legal status


2006-07-05 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20060117

2003-04-16 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030228

2002-12-18 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20021107

2002-12-18 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): BE CH DE ES FR GB IE IT LI NL

2000-12-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000904

2000-12-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): BE CH DE ES FR GB IE IT LI NL