EP 1058550 A1 20001213 - SUBSTITUTED SEMICARBAZIDES AND THE USE THEREOF
Title (en)
SUBSTITUTED SEMICARBAZIDES AND THE USE THEREOF
Title (de)
SUBSTITUIERTE SEMICARBAZIDE UND DEREN VERWENDUNG
Title (fr)
SEMICARBAZIDES SUBSTITUES ET LEUR UTILISATION
Publication
Application
Priority
- US 9902419 W 19990204
- US 7371098 P 19980204
Abstract (en)
[origin: WO9939712A1] This invention is related to substituted semicarbazides represented by Formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein: R1 and R2 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; R3, R4, R5 and R6 are independently hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl, or R3 and R4 is defined as above, and R5 and R6 together with the nitrogen atom to which they are attached form a heterocycle, including piperidine, piperazine, morpholine; A1 and A2 are independently aryl, heteroaryl, saturated or partially unsaturated carbocycle or satured or partially unsaturated heterocycle, any of which is optionally substituted; X is one of O, S, NR7, CH2, C(O), NR7C(O), C(O)NR7, SO, SO2 or a covalent bond; where R7 is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, haloalkyl, aryl, aminoalkyl, hydroxyalkyl, alkoxyalkyl or carboxyalkyl; n is 0, 1, 2 or 3. m is 0, 1, 2 or 3. The invention also is directed to the use of substituted semicarbazides for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as anticonvulsants, and as antimanic depressants, as anti-migraine agents, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
IPC 1-7
A61K 31/535; C07D 207/04; C07D 207/08; C07D 211/70; C07D 215/38; C07D 251/00; C07D 265/30; C07D 307/02; C07D 315/00; C07D 401/00; C07D 413/00
IPC 8 full level
A61K 31/175 (2006.01); A61K 31/341 (2006.01); A61K 31/351 (2006.01); A61K 31/357 (2006.01); A61K 31/36 (2006.01); A61K 31/381 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/505 (2006.01); A61K 31/53 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); A61P 23/02 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/08 (2006.01); A61P 25/24 (2006.01); C07C 281/06 (2006.01); C07D 215/20 (2006.01); C07D 239/26 (2006.01); C07D 239/34 (2006.01); C07D 239/38 (2006.01); C07D 239/42 (2006.01); C07D 251/12 (2006.01); C07D 307/02 (2006.01); C07D 307/38 (2006.01); C07D 307/42 (2006.01); C07D 307/52 (2006.01); C07D 307/54 (2006.01); C07D 307/56 (2006.01); C07D 307/58 (2006.01); C07D 307/66 (2006.01); C07D 307/68 (2006.01); C07D 309/12 (2006.01); C07D 317/64 (2006.01)
CPC (source: EP)
A61P 9/06 (2017.12); A61P 9/10 (2017.12); A61P 23/02 (2017.12); A61P 25/00 (2017.12); A61P 25/04 (2017.12); A61P 25/08 (2017.12); A61P 25/24 (2017.12); C07C 281/06 (2013.01)
Designated contracting state (EPC)
BE CH DE ES FR GB IE IT LI NL
DOCDB simple family (publication)
WO 9939712 A1 19990812; WO 9939712 A9 19991021; AU 2583199 A 19990823; AU 754681 B2 20021121; CA 2319484 A1 19990812; EP 1058550 A1 20001213; EP 1058550 A4 20021218; IL 137671 A0 20011031; JP 2002511387 A 20020416; MX PA00007585 A 20021017
DOCDB simple family (application)
US 9902419 W 19990204; AU 2583199 A 19990204; CA 2319484 A 19990204; EP 99905734 A 19990204; IL 13767199 A 19990204; JP 2000530210 A 19990204; MX PA00007585 A 19990204