Global Patent Index - EP 1058557 A1

EP 1058557 A1 2000-12-13 - ENHANCEMENT OF IMMUNITY BY INTRANASAL INOCULATION OF IL-12

Title (en)

ENHANCEMENT OF IMMUNITY BY INTRANASAL INOCULATION OF IL-12

Title (de)

STEIGERUNG DER IMMUNITÄT DURCH INTRANASALE VERABREICHUNG VON IL-12

Title (fr)

RENFORCEMENT DE L'IMMUNITE PAR INOCULATION INTRA-NASALE D'IL-12

Publication

EP 1058557 A1 (EN)

Application

EP 99911081 A

Priority

  • US 9904678 W
  • US 3518898 A

Abstract (en)

[origin: WO9944635A1] The present invention relates to a method of enhancing an immune response to a pathogen in a host using intranasal administration of interleukin-12 (IL-12). In one embodiment, the present invention relates to a method of inducing an immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. In another embodiment, the present invention relates to a method of enhancing an immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. In a particular embodiment, the present invention relates to a method of inducing an immune response to a mucosal pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of inducing a Th1-like immune response to a pathogen in a host, comprising administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen. The present invention also relates to a method of enhancing a mucosal immune response to a pathogen in a host, which comprises administering intranasally to the host an effective amount of IL-12 and an antigen of the pathogen.

IPC 1-7 (main, further and additional classification)

A61K 39/39; A61K 39/02; A61K 39/12; A61K 39/145

IPC 8 full level (invention and additional information)

A61K 9/00 (2006.01); A61K 38/00 (2006.01); A61K 39/002 (2006.01); A61K 39/02 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); A61K 39/39 (2006.01); A61P 31/00 (2006.01); A61P 33/00 (2006.01); A61P 37/04 (2006.01)

CPC (invention and additional information)

A61K 39/39 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 2039/543 (2013.01); A61K 2039/55538 (2013.01); A61K 2039/57 (2013.01); C12N 2760/16134 (2013.01)

Citation (search report)

See references of WO 9944635A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9944635 A1 19990910; AU 2980899 A 19990920; AU 747917 B2 20020530; CA 2322337 A1 19990910; CN 1298307 A 20010606; EP 1058557 A1 20001213; JP 2002505302 A 20020219; NZ 506650 A 20031128

INPADOC legal status


2007-10-17 [18R] REFUSED

- Ref Legal Event Code: 18R

- Effective date: 20070504

2003-07-16 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030603

2000-12-13 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000916

2000-12-13 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE