Global patent index - EP 1058732 A2

EP 1058732 A2 2000-12-13 - ATTENUATION OF BACTERIA: MATERIALS AND METHODS RELATING THERETO

Title (en)

ATTENUATION OF BACTERIA: MATERIALS AND METHODS RELATING THERETO

Title (de)

BAKTERIELLE ABSCHWÄCHUNG: WERKSTOFFE UND VERFAHREN DAFÜR

Title (fr)

ATTENUATION DE BACTERIES: MATIERES ET METHODES ASSOCIEES

Publication

EP 1058732 A2 (EN)

Application

EP 99937942 A

Priority

  • GB 9900675 W
  • GB 9804809 A

Abstract (en)

[origin: WO9945120A2] Attenuated microorganisms are prepared by mutating one or more genes selected from sopA, sopD, sipA, or a gene from within the pathogenicity island SPI-5, when the microorganism is Salmonella, or one or more homologous genes which correspond to said Salmonella genes, when the microorganism is another enteric bacteria. In comparison with the wild-type strains, the attenuated microorganisms have a reduced enteropathogenicity but substantially the same invasiveness. The attenuated microorganisms can be administered as vaccines against infection by enteric bacteria. Polypeptides encoded by sopA, pipD, orfX, pipC, pipB and pipA genes, variants thereof, and nucleic acids encoding those polypeptides, are also provided.

IPC 1-7 (main, further and additional classification)

C12N 15/31; A61K 35/74; A61K 39/112; A61K 48/00; C07K 14/255; C07K 16/12; C12N 1/21; C12N 1/36; C12N 15/74; C12Q 1/68; G01N 33/53

IPC 8 full level (invention and additional information)

C07K 14/255 (2006.01); C12N 1/21 (2006.01); C12N 1/36 (2006.01); C12N 15/31 (2006.01); A61K 39/00 (2006.01)

CPC (invention and additional information)

C07K 14/255 (2013.01); C12N 1/36 (2013.01); A61K 39/00 (2013.01); A61K 2039/51 (2013.01)

Citation (search report)

See references of WO 9945120A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9945120 A2 19990910; WO 9945120 A3 19991216; EP 1058732 A2 20001213; GB 9804809 D0 19980429

INPADOC legal status

2003-04-16 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020930

2001-09-26 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: INSTITUTE FOR ANIMAL HEALTH

- Ref Legal Event Code: RAP1

2001-08-08 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010621

2000-12-13 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000921

2000-12-13 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE