Global patent index - EP 1059932 A1

EP 1059932 A1 2000-12-20 - METHOD FOR REDUCING SUSCEPTIBILITY TO HIV INFECTION

Title (en)

METHOD FOR REDUCING SUSCEPTIBILITY TO HIV INFECTION

Title (de)

METHODE ZUR VERMINDERUNG DER EMPFINDLICHKEIT GEGENÜBER HIV-INFEKTIONEN

Title (fr)

PROCEDE POUR REDUIRE LA SENSIBILITE A L'INFECTION A VIH

Publication

EP 1059932 A1 (EN)

Application

EP 98964798 A

Priority

  • US 9827005 W
  • US 6835597 P
  • US 9847498 P

Abstract (en)

[origin: WO9932138A1] There is disclosed a method of reducing susceptibility of cells to infection by a retrovirus, comprising contacting the cells with an amount of a CD40 binding protein effective to reduce the expression of the chemokine receptor CCR5, and/or induce a post-entry block of the replication of the retrovirus. The method is useful in treating individuals infected with, or at risk of being infected with, HIV. CD40 binding proteins include CD40 ligand, monoclonal antibodies that specifically bind CD40, and combinations thereof. CD40 binding proteins may also be used in combination with other cytokines, including GM-CSF, IL-2 and IL-15.

IPC 1-7 (main, further and additional classification)

A61K 38/19; A61K 38/17

IPC 8 full level (invention and additional information)

A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/22 (2006.01); A61P 31/18 (2006.01); A61P 37/02 (2006.01)

CPC (invention and additional information)

A61K 38/193 (2013.01); A61K 38/177 (2013.01); A61K 38/2013 (2013.01); A61K 38/2086 (2013.01)

Combination set (CPC)

  1. A61K 38/177 + A61K 2300/00
  2. A61K 38/193 + A61K 2300/00
  3. A61K 38/2013 + A61K 2300/00
  4. A61K 38/2086 + A61K 2300/00

Citation (search report)

See references of WO 9932138A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9932138 A1 19990701; AU 2004199 A 19990712; CA 2313805 A1 19990701; EP 1059932 A1 20001220; IL 136731 D0 20010614; JP 2001526241 A 20011218

INPADOC legal status

2004-01-07 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030701

2003-06-18 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030502

2000-12-20 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000719

2000-12-20 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE