EP 1059932 A1 20001220 - METHOD FOR REDUCING SUSCEPTIBILITY TO HIV INFECTION
Title (en)
METHOD FOR REDUCING SUSCEPTIBILITY TO HIV INFECTION
Title (de)
METHODE ZUR VERMINDERUNG DER EMPFINDLICHKEIT GEGENÜBER HIV-INFEKTIONEN
Title (fr)
PROCEDE POUR REDUIRE LA SENSIBILITE A L'INFECTION A VIH
Publication
Application
Priority
- US 9827005 W 19981218
- US 6835597 P 19971219
- US 9847498 P 19980831
Abstract (en)
[origin: WO9932138A1] There is disclosed a method of reducing susceptibility of cells to infection by a retrovirus, comprising contacting the cells with an amount of a CD40 binding protein effective to reduce the expression of the chemokine receptor CCR5, and/or induce a post-entry block of the replication of the retrovirus. The method is useful in treating individuals infected with, or at risk of being infected with, HIV. CD40 binding proteins include CD40 ligand, monoclonal antibodies that specifically bind CD40, and combinations thereof. CD40 binding proteins may also be used in combination with other cytokines, including GM-CSF, IL-2 and IL-15.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 38/19 (2006.01); A61K 38/20 (2006.01); A61K 38/22 (2006.01); A61P 31/18 (2006.01); A61P 37/02 (2006.01)
CPC (source: EP)
A61K 38/177 (2013.01); A61K 38/193 (2013.01); A61K 38/2013 (2013.01); A61K 38/2086 (2013.01); A61P 31/18 (2017.12); A61P 37/02 (2017.12)
Citation (search report)
See references of WO 9932138A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9932138 A1 19990701; AU 2004199 A 19990712; CA 2313805 A1 19990701; EP 1059932 A1 20001220; IL 136731 A0 20010614; JP 2001526241 A 20011218
DOCDB simple family (application)
US 9827005 W 19981218; AU 2004199 A 19981218; CA 2313805 A 19981218; EP 98964798 A 19981218; IL 13673198 A 19981218; JP 2000525129 A 19981218